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- Application
- Activation (Act)
- Purpose
- Antioxidant, SIRT1 activator
- Characteristics
- Naturally occurring phenolic antioxidant. Displays antitumor and antiplatelet effects. Activates SIRT1 and increases longevity in yeast. Ameliorates ageing-related phenotypes by inhibition of cAMP phosphodiesterases. Stimulates increased expression of transthyretin which binds Aβ peptide and prevents its aggregation and toxicity. Attenuates Aβ-induced neurotoxicity by induction of autophagy. Rescues SIRT1-dependent adult stem cell decline.
- Purity
- >98 %
- Chemical Name
- 3,4',5-Trihydroxy-trans-stilbene
- Formula
- C14H12O3
- Solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
CI-994Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Tranylcypromine hemisulfate (±)Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Tenovin-1Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
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- Restrictions
- For Research Use only
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- Format
- Powder
- Storage
- -20 °C
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- Background
- 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol,Cell cycle,Epigenetics,Coagulation,Apoptosis inhibitor,Apoptosis inducer,Protein deacetylase,Antioxidant,Stem cells,Cell death,Immunology,Diabetes,Cancer,Neurodegeneration,Inflammation,Redox,Ageing,Chromatin
- Molecular Weight
- 228.3
- CAS-No
- 501-36-0
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