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- Application
- Inhibition (Inh)
- Purpose
- Acetyl-transferase NAT10 inhibitor
- Characteristics
- Potent and selective inhibitor of N-acetyltransferase 10 (NAT10) which is capable of acetylating microtubules and histones. Improves nuclear architecture, chromatin organization and fitness of both human lamin A/C-depleted cells and Hutchinson-Gilford progeria syndrome patient cells, normalizing progeric and aging cells. Enhances health span in a mouse model of human accelerated aging syndrome. Significantly reduces many of the defects associated with accumulation of the lamin A precursor, prelamin A. Inhibits NAT10-promoted metastasis which may be mediated by endothelial-to-mesenchymal transition in hepatocellular carcinoma.
- Purity
- >98 %
- Chemical Name
- 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
- Formula
- C15H14N4S
- Solubility
- Soluble in DMSO (up to 40 mg/ml)
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
CI-994Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Tranylcypromine hemisulfate (±)Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Tenovin-1Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
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- Restrictions
- For Research Use only
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- Format
- Powder
- Storage
- -20 °C
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- Background
- Epigenetics,Nuclear transport,Acetyltransferase,Cytoskeleton,Ageing,Posttranslational modification,Chromatin
- Molecular Weight
- 282.36
- CAS-No
- 949912-58-7
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