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PFI-2 HCl (R-)

Inh 1627607-87-7 (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
Catalog No. ABIN7233274
  • Application
    Inhibition (Inh)
    Purpose
    Methyltransferase SETD7 inhibitor
    Characteristics
    (R)-PFI-2 (1627607-87-7) is a potent (IC50 = 2nM) and selective SAM-dependent inhibitor of the lysine methyltransferase SETD7. It alters Hippo pathway signaling in MCF7 cells by altering YAP nuclear localization in a SETD7-dependent manner.
    Purity
    >98 %
    Chemical Name
    (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl-1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride
    Formula
    C23H25F4N3O3S HCl
    Solubility
    Soluble in DMSO (up to at least 25 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Epigenetics,Protein methyltransferase,Cancer,Posttranslational modification,Chromatin
    Molecular Weight
    535.98
    CAS-No
    1627607-87-7
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