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- Application
- Inhibition (Inh)
- Purpose
- Transcription inhibitor, Inhibits DNA methyltransferase
- Characteristics
- Inhibits DNA methyl transferase. A selective Sp1 inhibitor, it binds to GC rich DNA sequences, displacing Sp1 transcription factor binding to oncogene promoters, inhibitings their expression. Mithramycin A (at 10-200 nM) sensitizes tumor cells to TRAIL-induced apoptosis.
- Purity
- >98 %
- Formula
- C52H76O24
- Solubility
- Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml).
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Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
RadicicolInh 12772-57-5
Geldanamycin- FITCInh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate
NicotinamideInh 98-92-0 Pyridine-3-carboxylic acid amide
5-AzacytidineInh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one
SAHA (Vorinostat)Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid
Phenylbutyrate NaInh 1716-12-7 4-Phenylbutyric acid, sodium salt
CI-994Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide
Tranylcypromine hemisulfate (±)Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt
Tenovin-1Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide
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- Restrictions
- For Research Use only
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- Format
- Powder
- Precaution of Use
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GHS – Classification
Acute toxicity, Oral (Category 4), H302 - Storage
- -20 °C
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- Background
- A2371, Antibiotic LA 7017, Aureolic Acid, NSC 24559, PA 144, Plicamycin,Epigenetics,Chromatin,DNA methyltransferase,RNA,Antibiotic,Cell death,Infectious disease,Apoptosis inducer,Transcription
- Molecular Weight
- 1085.15
- CAS-No
- 18378-89-7
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