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Lomeguatrib

Inh 192441-08-0 2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
Catalog No. ABIN7233266
  • Application
    Inhibition (Inh)
    Purpose
    MGMT inhibitor
    Characteristics
    Lomeguatrib is a potent (IC50 = 9 nM) inhibitor of O6-Methylguanine-DNA Methyltransferase (MGMT), an important DNA repair protein. It is currently being investigated in cancers that have acquired resistant to the chemotherapeutic temozolomide, as well as other chemotherapeutics.
    Purity
    >98 %
    Chemical Name
    2-Amino-6-[(4-bromo-2-thienyl)methoxy]-9H-purine
    Formula
    C10H8BrN5O3S
    Solubility
    Soluble in DMSO (up to 10 mg/ml with warming)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    O6-(4-Bromothenyl)guanine,Epigenetics,Posttranslational modification,DNA Methyltransferase,Cancer,Chromatin,DNA repair
    Molecular Weight
    326.2
    CAS-No
    192441-08-0
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