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IOX 1

Inh Cell-permeable 5852-78-8 8-Hydroxy-5-quinolinecarboxylic acid
Catalog No. ABIN7233262
  • Application
    Inhibition (Inh)
    Purpose
    JMJD demethylase inhibitor
    Characteristics
    Inhibits the JMJD family of 2-oxoglutarate-dependent histone demethylases. IC50 = 0.12, 0.07, 0.2, 0.3, 0.6, and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively1. A broad spectrum 2-oxoglutarate oxygenase inhibitor which may be used to study hypoxic signaling. Cell permeable
    Purity
    >98 %
    Chemical Name
    8-Hydroxy-5-quinolinecarboxylic acid
    Formula
    C10H7NO3
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 20 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    RT
  • Background
    5-Carboxy-8HQ,Epigenetics,Protein demethylase,Oxidative stress,Posttranslational modification,Chromatin
    Molecular Weight
    189.17
    CAS-No
    5852-78-8
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