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GSK-J4

Inh Cell-permeable 1373423-53-0 N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Catalog No. ABIN7233259
  • Application
    Inhibition (Inh)
    Purpose
    JMJ H3K27 Demethylase inhibitor (cell permeable)
    Characteristics
    Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J1. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies.
    Purity
    >98 %
    Chemical Name
    N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
    Formula
    C24H27N5O2
    Permeability
    Cell-permeable
    Solubility
    Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
  • Restrictions
    For Research Use only
  • Format
    Wax
    Storage
    -20 °C
  • Background
    Epigenetics,Posttranslational modification,Protein demethylase,Immunology,Inflammation,Cytokine,Chromatin
    Molecular Weight
    417.48
    CAS-No
    1373423-53-0
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