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EPZ015666

Inh 1616391-65-1 (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
Catalog No. ABIN7233251
  • Application
    Inhibition (Inh)
    Purpose
    Potent and selective PRMT5 inhibitor
    Characteristics
    Potent (IC50 = 22 nM) and selective inhibitor of arginine methyltransferase 5 (PRMT5). PRMT5 dimethylates Myc, and its inhibition by EPZ015666 suppresses cell growth and induces apoptosis and/or cell cycle arrest in medulloblastoma and retinoblastoma cells. It also sensitizes glioblastoma cells to mTOR inhibitor PP242.
    Purity
    >98 %
    Chemical Name
    (S)-N-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
    Formula
    C20H25N5O3
    Solubility
    Soluble in DMSO (up to 20 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Epigenetics,Proliferation,Protein methyltransferase,Cancer,Posttranslational modification,Chromatin
    Molecular Weight
    383.44
    CAS-No
    1616391-65-1
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