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CUDC-101

Inh 1012054-59-9 7-((4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
Catalog No. ABIN7233246
  • Application
    Inhibition (Inh)
    Purpose
    Dual HDAC and EGFR inhibitor
    Characteristics
    A novel hybrid dual-acting HDAC and receptor tyrosine kinase inhibitor. It is a potent HDAC inhibitor which also inhibits EGFR and HER2, IC50 = 4.4, 2.4 and 15.7 nM respectively. It not only blocks EGFR and HER2 but also attenuates multiple compensatory pathways such as AKT, HER3 and MET which enable tumor cells to escape the effects of conventional EGFR/HER2 inhibitors.
    Purity
    >98 %
    Chemical Name
    7-((4-((3-Ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)oxy)-N-hydroxyheptanamide
    Formula
    C24H26N4O4
    Solubility
    Soluble in DMSO (up to 25 mg/ml)
  • Restrictions
    For Research Use only
  • Format
    Powder
    Storage
    -20 °C
  • Background
    Epigenetics,Posttranslational modification,Kinase,Protein deacetylase,Cancer,Chromatin,AKT
    Molecular Weight
    434.49
    CAS-No
    1012054-59-9
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