For best experience we recommend to activate Javascript in your browser.

Bosutinib (SKI-606)

InhA, Func 380843-75-4

Catalog No. ABIN3220262

Datasheet as PDF

Application

Inhibition Assay (InhA), Functional Studies (Func)

Purpose

Bosutinib is a Bcr-Abl kinase inhibitor for the treatment of Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML). Compared to other tyrosine kinase inhibitors, it has a more favourable hematologic toxicity profile. FDA approved on September 4, 2012.

Characteristics

Tradename: Bosutinib
Source of Compound: synthetic
Target: MAPK inhibitor,Src inhibitor,Bcr-Abl inhibitor,CaMK inhibitor,CDK inhibitor
Receptor: MAPKK2, MAPKKK2,ABL1, Lyn, HCK, Src,Breakpoint cluster region protein(BCR),Bcr-Abl ,CaMK,CDK 2

Purification

All the products are sent with COA, HPLC and NMR inspection report to guarantee the quality.

Purity

99 %

Formula

C26H29Cl2N5O3

Solubility

Soluble in DMSO
Geldanamycin
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Radicicol
Inh 12772-57-5

Geldanamycin- FITC
Inh 30562-34-6 (4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1] docosa-1(21),4,6,10,18-pentaen-9-yl carbamate

Nicotinamide
Inh 98-92-0 Pyridine-3-carboxylic acid amide

5-Azacytidine
Inh Cell-permeable 320-67-2 4-Amino-1-ß-D-ribofuranosyl-1,3,5-triazin-2(1H)-one

SAHA (Vorinostat)
Inh Cell-permeable 149647-78-9 Suberoylanilide-hydroxamic acid

Phenylbutyrate Na
Inh 1716-12-7 4-Phenylbutyric acid, sodium salt

CI-994
Inh 112522-64-2 4-(Acetylamino)-N-(2-aminophenyl)benzamide

Tranylcypromine hemisulfate (±)
Inh Cell-permeable 13492-01-8 Trans (±)-2-phenylcyclopropanamine, hemisulfate salt

Tenovin-1
Inh 380315-80-0 N-[(4-Acetamidophenyl)carbamothioyl]-4-tert-butylbenzamide

Application Notes

Optimal working dilution should be determined by the investigator.

Restrictions

For Research Use only
Format

Solid

Storage

-20 °C

Storage Comment

For the majority of compounds, they could be dissolved in DMSO or other organic solvent.
Their stock solution can be stored at -20°C for up to 3 months and aliquoted for sampling convenience.
Several freeze/thaw cycles should not damage the activity of our small molecule products.
However, in many instances the aqueous solutions of some compounds need to be made fresh and cannot be stored. For these compounds, their solution should be prepared just before use and stored no longer than 24 hours.

Expiry Date

24 months
Background

Cell cycle/Checkpoint,MAPK Signaling,Neuroscience,Tyrosine Kinase/Adaptors

Molecular Weight

530.45 g/mol

CAS-No

380843-75-4