Agitoxin-2
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- Application
- Blocking Reagent (BR), Inhibition Assay (InhA)
- Purpose
- Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels
- Sequence
- AA sequence: Gly-Val-Pro-Ile-Asn-Val-Ser-Cys8-Thr-Gly -Ser-Pro-Gln-Cys14-Ile-Lys-Pro-Cys18-Lys-Asp- Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys28-Met-Asn -Arg-Lys-Cys33-His-Cys35-Thr-Pro-Lys-OH br>Disulfide bonds: Cys8-Cys28, Cys14-Cys33, Cys18-Cys35
- Specificity
- Agitoxin-2 is a potent blocker of Kv1.1 and Kv1.3 channels
- Characteristics
- Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated Kv1.3 and Kv1.1 channels. Agitoxin-2 inhibits Kv1.3 with an IC50 value of around 200 pM and Kv1.1 with an IC50 value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.
- Formula
- C169H278N54O48S8
- Solubility
- water and saline buffer
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- Restrictions
- For Research Use only
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- Format
- Powder
- Storage
- -20 °C
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- Molecular Weight
- 4090.89 Da
- CAS-No
- 168147-41-9
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