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Integrin beta 4 Products

(Integrin beta 4 (ITGB4))
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Integrin beta 4 Categories

Integrin beta 4 Antibodies

High quality antibodies with extensive validation data.

Integrin beta 4 ELISA Kits

Reliable ELISA kits for a wide range of species.

Integrin beta 4 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Integrin beta 4 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, FACS, ELISA
Validations
  • (1)
  • (6)
Cat. No. ABIN1724805
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, FACS, ELISA, ICC, Neut
Validations
  • (6)
Cat. No. ABIN5611133
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (4)
Cat. No. ABIN7156486
Quantity 100 μg
Datasheet Datasheet

Recommended Integrin beta 4 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6956849
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380463
Quantity 2 x 96 tests
Datasheet Datasheet
Reactivity Cow
Analytical Method Quantitative
Validations
Cat. No. ABIN1055086
Quantity 96 tests
Datasheet Datasheet

Recommended Integrin beta 4 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123472
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1308213
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN6388181
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our Integrin beta 4 products

Giampieri, Piva, Occhipinti, Bittoni, Righetti, Pagliaretta, Murrone, Bianchi, Amantini, Giulietti, Ricci, Principato, Santoni, Berardi, Cascinu: "Clinical impact of different exosomes' protein expression in pancreatic ductal carcinoma patients treated with standard first line palliative chemotherapy." in: PLoS ONE, Vol. 14, Issue 5, pp. e0215990, (2019) (PubMed).

Russo, Klein, Lim, Solis, Machado, Hiroyasu, Nabai, Shen, Zeglinski, Zhao, Oram, Lennox, Van Laeken, Carr, Crawford, Franzke, Overall, Granville: "Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction." in: Scientific reports, Vol. 8, Issue 1, pp. 9690, (2018) (PubMed).

Rajan, Persson, Frängsmyr, Olofsson, Sandblad, Heino, Takada, Mould, Schnapp, Gall, Arnberg: "Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells." in: Scientific reports, Vol. 8, Issue 1, pp. 10019, (2018) (PubMed).

Storm, Persson, Skalman, Frängsmyr, Lindström, Rankin, Lundmark, Domellöf, Arnberg: "Human Adenovirus Type 37 Uses αVβ1 and α3β1 Integrins for Infection of Human Corneal Cells." in: Journal of virology, Vol. 91, Issue 5, (2017) (PubMed).

Feng, Chen, Ding, Fu, Yang, Deng, Zeng: "P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite." in: Journal of neuroinflammation, Vol. 12, pp. 190, (2016) (PubMed).

Hoshino, Costa-Silva, Shen, Rodrigues, Hashimoto, Tesic Mark, Molina, Kohsaka, Di Giannatale, Ceder, Singh, Williams, Soplop, Uryu, Pharmer, King, Bojmar, Davies, Ararso, Zhang, Zhang, Hernandez et al.: "Tumour exosome integrins determine organotropic metastasis. ..." in: Nature, Vol. 527, Issue 7578, pp. 329-35, (2015) (PubMed).

Wu, Zhou, Duan, Wang, Xiao, Duan, Li, Li, Wan, Liu, Song, Zhou, Huang, Wang: "Reconstruction of auto-tissue-engineered lamellar cornea by dynamic culture for transplantation: a rabbit model." in: PLoS ONE, Vol. 9, Issue 4, pp. e93012, (2014) (PubMed).

Li, Rossen, Sinn, Hornick, Steines, Karp, Ernst, Adam, Moninger, Levasseur, Zabner: "Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease." in: PLoS ONE, Vol. 8, Issue 12, pp. e83624, (2014) (PubMed).

Hsu, Wu, Hung, Lin, Huang, Kuo: "Galectin-1 promotes lung cancer tumor metastasis by potentiating integrin α6β4 and Notch1/Jagged2 signaling pathway." in: Carcinogenesis, Vol. 34, Issue 6, pp. 1370-81, (2013) (PubMed).

Liu, Qin, Liu, Xiang: "Downregulation of integrin β4 decreases the ability of airway epithelial cells to present antigens." in: PLoS ONE, Vol. 7, Issue 4, pp. e32060, (2012) (PubMed).

Synonyms and alternative names related to Integrin beta 4

integrin subunit beta 4 (ITGB4), integrin beta 4 (Itgb4), integrin subunit beta 4 (Itgb4), AA407042, C230078O20, CD104

Protein level used designations for Integrin beta 4

  • integrin beta 4
  • integrin beta-4
  • CD104 antigen
  • GP150
  • integrin beta-4 subunit
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