INSIG1 Products
(Insulin Induced Gene 1 (INSIG1))
Categories
Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009].
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Featured INSIG1 Categories
INSIG1 Antibodies
High quality antibodies with extensive validation data.
Recommended INSIG1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7156348
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6262599
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
Cat. No.
ABIN652887
Quantity
400 μL
Datasheet
Datasheet
Recommended INSIG1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6228955
Quantity
96 tests
Datasheet
Datasheet
Recommended INSIG1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7422967
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3109916
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3124684
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our INSIG1 products
: "LncRNA as ceRNAs may be involved in lactation process." in: Oncotarget, Vol. 8, Issue 58, pp. 98014-98028, (2017) (PubMed).: "Analysis of the protein network of cholesterol homeostasis in different brain regions: an age and sex dependent perspective." in: Journal of cellular physiology, Vol. 228, Issue 7, pp. 1561-7, (2013) (PubMed).
: "Regulation of cholesterol biosynthetic pathway in different regions of the rat central nervous system." in: Acta physiologica (Oxford, England), Vol. 206, Issue 1, pp. 62-71, (2012) (PubMed).
: "Short- and long-term regulation of 3-hydroxy 3-methylglutaryl coenzyme A reductase by a 4-methylcoumarin." in: Biochimie, Vol. 93, Issue 7, pp. 1165-71, (2011) (PubMed).
: "Sex differences in hepatic regulation of cholesterol homeostasis." in: The Journal of endocrinology, Vol. 198, Issue 3, pp. 635-43, (2008) (PubMed).
: "Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression." in: Molecular pharmacology, Vol. 73, Issue 4, pp. 1282-9, (2008) (PubMed).
: "Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake." in: Cell metabolism, Vol. 3, Issue 1, pp. 15-24, (2006) (PubMed).
: "Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins." in: The Journal of clinical investigation, Vol. 115, Issue 9, pp. 2489-98, (2005) (PubMed).
Synonyms and alternative names related to INSIG1
insulin induced gene 1 (INSIG1), insulin induced gene 1 (insig1), insulin induced gene 1 L homeolog (insig1.L), insulin induced gene 1 (Insig1), 1810013C12Rik, cl-6, CL-6, cl6, CL6, fb55a03, fi35b10, Insig-1, INSIG-1, wu:fb55a03, wu:fi35b10, zgc:55439Protein level used designations for INSIG1
- insulin induced gene 1
- INSIG-1
- insulin-induced gene 1 protein
- INSIG-1 membrane protein
- growth response protein (CL-6)
- immediate-early protein CL-6
- insulin-induced growth response protein CL-6
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