INPP5D Products
(Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured INPP5D Categories
INPP5D Antibodies
High quality antibodies with extensive validation data.
INPP5D ELISA Kits
Reliable ELISA kits for a wide range of species.
INPP5D Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended INPP5D Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN6213625
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP
Validations
- (3)
Cat. No.
ABIN7127806
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF, ICC
Validations
- (3)
Cat. No.
ABIN6265066
Quantity
100 μL
Datasheet
Datasheet
Recommended INPP5D ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (3)
Cat. No.
ABIN4889790
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956751
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
- (2)
Cat. No.
ABIN4889791
Quantity
96 tests
Datasheet
Datasheet
Recommended INPP5D Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3095410
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3137223
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2723485
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our INPP5D products
: "Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1: a meaningful and independent marker to predict stroke in the Chinese population." in: Journal of molecular neuroscience : MN, Vol. 52, Issue 4, pp. 507-14, (2014) (PubMed).: "Expression of glutamate carboxypeptidase II in human brain." in: Neuroscience, Vol. 144, Issue 4, pp. 1361-72, (2007) (PubMed).
: "Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs." in: The Prostate, Vol. 68, Issue 2, pp. 171-82, (2007) (PubMed).
: "Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer." in: The EMBO journal, Vol. 25, Issue 6, pp. 1375-84, (2006) (PubMed).
: "Ras and its signals diffuse through the cell on randomly moving nanoparticles." in: Cancer research, Vol. 66, Issue 4, pp. 1974-81, (2006) (PubMed).
: "Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling." in: Molecular and cellular biology, Vol. 25, Issue 15, pp. 6722-33, (2005) (PubMed).
: "SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets." in: The Journal of biological chemistry, Vol. 279, Issue 31, pp. 32196-204, (2004) (PubMed).
: "Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane." in: Molecular and cellular biology, Vol. 24, Issue 15, pp. 6799-810, (2004) (PubMed).
: "SH2-containing inositol 5-phosphatases 1 and 2 in blood platelets: their interactions and roles in the control of phosphatidylinositol 3,4,5-trisphosphate levels." in: The Biochemical journal, Vol. 376, Issue Pt 1, pp. 199-207, (2003) (PubMed).
: "Evidence for a positive role of SHIP in the BCR-ABL-mediated transformation of primitive murine hematopoietic cells and in human chronic myeloid leukemia." in: Blood, Vol. 102, Issue 8, pp. 2976-84, (2003) (PubMed).
Synonyms and alternative names related to INPP5D
inositol polyphosphate-5-phosphatase D (INPP5D), phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100446045), inositol polyphosphate-5-phosphatase D (inpp5d), inositol polyphosphate 5-phosphatase (EHI_159880), inositol polyphosphate 5-phosphatase (EHI_153490), inositol polyphosphate-5-phosphatase D L homeolog (inpp5d.L), phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 (LOC100380693), inositol polyphosphate-5-phosphatase D (Inpp5d), 13.t00027, 256.t00004, AI323613, hp51CN, INPP5D, s-SHIP, ship, SHIP, SHIP-1, ship1, SHIP1, SIP-145Protein level used designations for INPP5D
- inositol polyphosphate-5-phosphatase, 145kDa
- SH2 containing inositol phosphatase
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
- phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1-like
- SH2 domain-containing inositol 5'-phosphatase 1
- SH2 domain-containing inositol phosphatase 1
- SH2 domain-containing inositol-5'-phosphatase 1
- SHIP-1
- phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
- Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1
- SH2 containing inositol phosphotase
- SH2-containing inositol phosphatase SHIP
- SIP-145
- Src homology 2 domain-containing inositol-5-phosphatase
- inositol polyphosphate-5-phosphatase of 145 kDa
- inositol polyphosphate-5-phosphatase, 145 kDa
- p150Ship
- Inositol polyphosphate-5-phosphatase 145 kDa
- Inositol polyphosphate-5-phosphatase, 145 kDa
- signaling inositol polyphosphate 5 phosphatase SIP-145
Did you look for something else?
- INPP5B
- INPP5A
- INPP4B
- INPP4A
- INPP1
- Inositol-3-Phosphate Synthase 1
- Inositol Polyphosphate Phosphatase-Like 1
- Inosine 5'-Phosphate Dehydrogenase 1
- Inorganic Phosphate Transporter 1
- INO80E
- INO80C
- INO80B
- INO80
- Inner Centromere Protein Antigens 135/155kDa
- INMT
- INIP
- Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein
- Inhibin, beta A
- Inhibin alpha
- Inhibin
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