IMPA1 Products
(Inositol(myo)-1(or 4)-Monophosphatase 1 (IMPA1))
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This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009].
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Featured IMPA1 Categories
IMPA1 Antibodies
High quality antibodies with extensive validation data.
IMPA1 ELISA Kits
Reliable ELISA kits for a wide range of species.
IMPA1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IMPA1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF
Validations
- (11)
Cat. No.
ABIN6142429
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA
Validations
- (3)
Cat. No.
ABIN7246232
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (1)
Cat. No.
ABIN561484
Quantity
50 μL
Datasheet
Datasheet
Recommended IMPA1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967605
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951504
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1138077
Quantity
96 tests
Datasheet
Datasheet
Recommended IMPA1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123442
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307883
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2130139
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IMPA1 products
: "An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons." in: Nature neuroscience, Vol. 13, Issue 3, pp. 291-301, (2010) (PubMed).: "A long hangover from party drugs: residual proteomic changes in the hippocampus of rats 8 weeks after ?-hydroxybutyrate (GHB), 3,4-methylenedioxymethamphetamine (MDMA) or their combination." in: Neurochemistry international, Vol. 56, Issue 8, pp. 871-7, (2010) (PubMed).
Synonyms and alternative names related to IMPA1
inositol monophosphatase 1 (impa1), inositol(myo)-1(or 4)-monophosphatase 1 (impa1), inositol (myo)-1(or 4)-monophosphatase 1 (Impa1), inositol monophosphatase 1 (Impa1), inositol monophosphatase (impa1), inositol monophosphatase 1 (IMPA1), inositol(myo)-1(or 4)-monophosphatase 1 S homeolog (impa1.S), inositol(myo)-1(or 4)-monophosphatase 1 (IMPA1), 2610002K09Rik, 2900059K10Rik, AI325909, IMP, IMPA, impa, zgc:100926Protein level used designations for IMPA1
- inositol monophosphatase 1
- Inositol monophosphatase
- IMP 1
- IMPase 1
- inositol-1(or 4)-monophosphatase 1
- lithium-sensitive myo-inositol monophosphatase A1
- myo-inositol monophosphatase
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