IL6RA Products
(Interleukin 6 Receptor, alpha (IL6RA))
Categories
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.[provided by RefSeq, May 2011].
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Featured IL6RA Categories
IL6RA Antibodies
High quality antibodies with extensive validation data.
IL6RA ELISA Kits
Reliable ELISA kits for a wide range of species.
IL6RA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL6RA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
FACS, IF (cc), IF (p), ELISA, IHC (fro), IHC (p)
Validations
- (2)
- (2)
Cat. No.
ABIN734693
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB
Validations
- (1)
Cat. No.
ABIN3181401
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
ELISA
Validations
Cat. No.
ABIN1686786
Quantity
100 μg
Datasheet
Datasheet
Recommended IL6RA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968019
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6719752
Quantity
1 kit
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1138704
Quantity
96 tests
Datasheet
Datasheet
Recommended IL6RA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275036
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275037
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275024
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IL6RA products
: "STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection." in: The Journal of experimental medicine, Vol. 215, Issue 4, pp. 1079-1090, (2019) (PubMed).: "Macrophagic control of the response to uropathogenic E. coli infection by regulation of iron retention in an IL-6-dependent manner." in: Immunity, inflammation and disease, Vol. 4, Issue 4, pp. 413-426, (2018) (PubMed).
: "Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells." in: Arthritis research & therapy, Vol. 19, Issue 1, pp. 137, (2017) (PubMed).
: "Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing." in: The American journal of pathology, Vol. 188, Issue 2, pp. 474-490, (2017) (PubMed).
: "Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling." in: Scientific reports, Vol. 7, pp. 44053, (2017) (PubMed).
: "Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 121, (2017) (PubMed).
: "IL-6 trans-signaling is another pathway to upregulate Osteopontin." in: Cytokine, Vol. 90, pp. 88-95, (2016) (PubMed).
: "Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium." in: PLoS ONE, Vol. 11, Issue 5, pp. e0155161, (2016) (PubMed).
: "Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells." in: PLoS ONE, Vol. 10, Issue 6, pp. e0130395, (2015) (PubMed).
: "Easy and rapid binding assay for functional analysis of disulfide-containing peptides by a pull-down method using a puromycin-linker and a cell-free translation system." in: Biology, Vol. 4, Issue 1, pp. 161-72, (2015) (PubMed).
Synonyms and alternative names related to IL6RA
interleukin 6 receptor (Il6r), interleukin 6 receptor (IL6R), interleukin 6 receptor, alpha (Il6ra), CD126, gp80, IL-6R, IL-6R-1, IL-6RA, IL6Q, Il6r, IL6R1, Il6ra, IL6RA, IL6RQProtein level used designations for IL6RA
- IL-6 receptor subunit alpha
- IL-6R 1
- IL-6R subunit alpha
- IL-6R-alpha
- IL-6RA
- interleukin 6 receptor, alpha
- interleukin-6 receptor subunit alpha
- CD126 antigen
- membrane glycoprotein 80
- IL-6 receptor alpha chain
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