IL21 Receptor Products
(Interleukin 21 Receptor (IL21R))
Categories
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010].
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Featured IL21 Receptor Categories
IL21 Receptor Antibodies
High quality antibodies with extensive validation data.
IL21 Receptor ELISA Kits
Reliable ELISA kits for a wide range of species.
IL21 Receptor Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL21 Receptor Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
ELISA, FACS
Validations
- (4)
Cat. No.
ABIN7193230
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7156852
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (1)
Cat. No.
ABIN748148
Quantity
100 μL
Datasheet
Datasheet
Recommended IL21 Receptor ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957098
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN625319
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6384626
Quantity
96 tests
Datasheet
Datasheet
Recommended IL21 Receptor Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275021
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275014
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275007
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IL21 Receptor products
: "Gene Expression Profile Signature of Aggressive Waldenström Macroglobulinemia with Chromosome 6q Deletion." in: BioMed research international, Vol. 2018, pp. 6728128, (2019) (PubMed).: "Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer." in: Cells, Vol. 8, Issue 9, (2019) (PubMed).
: "IL-11 Induces Encephalitogenic Th17 Cells in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 203, Issue 5, pp. 1142-1150, (2019) (PubMed).
: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." in: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).
: "Increased IL-21/IL-21R expression and its proinflammatory effects in autoimmune thyroid disease." in: Cytokine, Vol. 72, Issue 2, pp. 160-5, (2015) (PubMed).
: "IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 11, pp. 5139-49, (2015) (PubMed).
: "CD4+ T cell-derived IL-21 and deprivation of CD40 signaling favor the in vivo development of granzyme B-expressing regulatory B cells in HIV patients." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 194, Issue 8, pp. 3768-77, (2015) (PubMed).
: "Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity." in: The Journal of experimental medicine, Vol. 209, Issue 3, pp. 581-96, (2012) (PubMed).
: "Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription." in: Immunology, Vol. 132, Issue 4, pp. 540-8, (2011) (PubMed).
: "IL-21 promotes skin recruitment of CD4(+) cells and drives IFN-?-dependent epidermal hyperplasia." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 9, pp. 5435-42, (2011) (PubMed).
Synonyms and alternative names related to IL21 Receptor
interleukin 21 receptor (IL21R), interleukin 21 receptor, tandem duplicate 1 (il21r.1), interleukin 21 receptor (Il21r), CD360, il-21ra.a, IL21R, NILRProtein level used designations for IL21 Receptor
- interleukin-21 receptor
- interleukin 21 receptor
- interleukin 21 receptor alpha.a
- IL-21 receptor
- novel interleukin receptor
- IL-21R
- LR-beta
- NR8
- lymphocyte receptor beta
- novel cytokine receptor 8
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