IL12RB2 Products
(Interleukin 12 Receptor, beta 2 (IL12RB2))
Categories
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012].
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Featured IL12RB2 Categories
IL12RB2 Antibodies
High quality antibodies with extensive validation data.
IL12RB2 ELISA Kits
Reliable ELISA kits for a wide range of species.
IL12RB2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL12RB2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (5)
Cat. No.
ABIN747878
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, FACS, IHC (p)
Validations
- (2)
Cat. No.
ABIN1904911
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (2)
Cat. No.
ABIN517103
Quantity
100 μg
Datasheet
Datasheet
Recommended IL12RB2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957019
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN4883298
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730312
Quantity
96 tests
Datasheet
Datasheet
Recommended IL12RB2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
- (1)
Cat. No.
ABIN7320555
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307683
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307682
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our IL12RB2 products
: "POSH Regulates CD4+ T Cell Differentiation and Survival." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 196, Issue 10, pp. 4003-13, (2016) (PubMed).: "Multiplex immunoassay characterization and species comparison of inflammation in acute and non-acute ischemic infarcts in human and mouse brain tissue." in: Acta neuropathologica communications, Vol. 4, Issue 1, pp. 100, (2016) (PubMed).
: "Poria Attenuates Idiosyncratic Liver Injury Induced by Polygoni Multiflori Radix Praeparata." in: Frontiers in pharmacology, Vol. 7, pp. 386, (2016) (PubMed).
: "Pro-inflammatory effects of interleukin-35 in rheumatoid arthritis." in: Cytokine, Vol. 73, Issue 1, pp. 36-43, (2015) (PubMed).
: "Anti-inflammatory cytokines directly inhibit innate but not adaptive CD8+ T cell functions." in: Journal of virology, Vol. 88, Issue 13, pp. 7474-84, (2014) (PubMed).
: "Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages." in: Nature immunology, Vol. 12, Issue 6, pp. 551-9, (2011) (PubMed).
: "Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 12, pp. 6165-72, (2002) (PubMed).
: "Differentiation of murine NK cells into distinct subsets based on variable expression of the IL-12R beta 2 subunit." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 9, pp. 4985-93, (2000) (PubMed).
: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).
: "Role of IL-12 in intrathymic negative selection." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4349-59, (1999) (PubMed).
Synonyms and alternative names related to IL12RB2
interleukin 12 receptor subunit beta 2 (IL12RB2), interleukin 12 receptor, beta 2 (Il12rb2), interleukin 12 receptor subunit beta 2 (Il12rb2), A930027I18Rik, Ifnm, IL-12RB2, IL12RB2Protein level used designations for IL12RB2
- interleukin 12 receptor, beta 2
- interleukin 12 receptor beta-2
- interleukin-12 receptor subunit beta-2
- interleukin-12 receptor subunit beta-2-like
- IL-12 receptor subunit beta-2
- IL-12R subunit beta-2
- IL-12R-beta-2
- interferon response to microorganisms
- interleukin-12 receptor beta-2 chain
- IL-12RB2
- interleukin-12 receptor beta 2
- IL-12 receptor beta-2
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