IL12RB1 Products
(Interleukin 12 Receptor beta 1 (IL12RB1))
Categories
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Featured IL12RB1 Categories
IL12RB1 Antibodies
High quality antibodies with extensive validation data.
IL12RB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
IL12RB1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL12RB1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (1)
- (1)
Cat. No.
ABIN747863
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Rat
Application
IHC, IF
Validations
- (2)
Cat. No.
ABIN7256826
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (2)
Cat. No.
ABIN517100
Quantity
100 μL
Datasheet
Datasheet
Recommended IL12RB1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957018
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730742
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730741
Quantity
96 tests
Datasheet
Datasheet
Recommended IL12RB1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275013
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN6731329
Quantity
200 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307680
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our IL12RB1 products
: "Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege." in: PLoS ONE, Vol. 9, Issue 4, pp. e96120, (2014) (PubMed).: "Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency." in: The Journal of allergy and clinical immunology, Vol. 131, Issue 4, pp. 1146-56, 1156.e1-5, (2013) (PubMed).
: "IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia." in: Blood, Vol. 120, Issue 18, pp. 3774-82, (2012) (PubMed).
: "Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo." in: Leukemia, Vol. 26, Issue 6, pp. 1365-74, (2012) (PubMed).
: "Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans." in: Journal of dermatological science, Vol. 57, Issue 3, pp. 199-206, (2010) (PubMed).
: "Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription." in: Cellular immunology, Vol. 241, Issue 1, pp. 7-13, (2006) (PubMed).
: "A novel form of complete IL-12/IL-23 receptor beta1 deficiency with cell surface-expressed nonfunctional receptors." in: Blood, Vol. 104, Issue 7, pp. 2095-101, (2004) (PubMed).
: "IL-12 receptor beta 2 (IL-12R beta 2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 11, pp. 6221-8, (2000) (PubMed).
: "Characterization of mouse interleukin-12 p40 homodimer binding to the interleukin-12 receptor subunits." in: European journal of immunology, Vol. 29, Issue 6, pp. 2007-13, (1999) (PubMed).
: "Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 5, pp. 2174-9, (1998) (PubMed).
Synonyms and alternative names related to IL12RB1
interleukin 12 receptor subunit beta 1 (Il12rb1), interleukin 12 receptor subunit beta 1 (IL12RB1), interleukin 12 receptor, beta 1 (Il12rb1), CD212, IL-12R, IL-12R-BETA1, IL-12R[b], Il12rb, IL12RB, IL12RB1Protein level used designations for IL12RB1
- interleukin-12 receptor subunit beta-1
- interleukin 12 receptor, beta 1
- IL12 receptor beta 1 subunit
- interleukin-12 receptor subunit beta-1-like
- IL-12 receptor beta component
- IL-12 receptor subunit beta-1
- IL-12R subunit beta-1
- interleukin-12 receptor beta-1 chain
- IL-12R-beta-1
- Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)
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