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IL12B Proteins

(Interleukin 12 beta (IL12B))

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].

recommended

IL12B Protein (AA 23-328) (His tag) (ABIN7275396)

IL12B Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE

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recommended

IL12B Protein (AA 23-328) (His tag) (ABIN7275395)

IL12B Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

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recommended

IL12B Protein (AA 23-328) (His tag) (ABIN1019696)

IL12B Origin: Human Host: Tobacco (Nicotiana benthamiana) Recombinant > 97 % by SDS polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue. WB, Imm

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IL12B Proteins by Origin

Find IL12B Proteins for a variety of species such as anti-Human IL12B, anti-Mouse IL12B, anti-Goat IL12B. The species listed below are among those available. Click on a link to go to the corresponding products.

IL12B Proteins by Source

Here you will find IL12B Proteins proteins organized by several key sources. By clicking on a link, you can access the products. For additional sources, please use our search function.

IL12B Proteins by Protein Type

Here you can find IL12B Proteins proteins categorized by available protein types. Additional protein types can be located using our search function.

IL12B Proteins by Application

Find IL12B Proteins validated for a specific application such as WB, SDS, ELISA, Imm. Some of the available applications are listed below. Click on a link to go to the corresponding products.

IL12B Proteins by Biological Activity

Find IL12B Proteins with a specific Biological Activity. The Biological Activity listed below are among those available. Click on a link to go to the corresponding products.

Popular IL12B Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

IL12B Protein (AA 23-328) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN7275396

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (AA 23-328) (His tag)

Reactivity Cynomolgus

Source HEK-293 Cells

Validations

Cat. No. ABIN7275395

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (AA 23-328) (His tag)

Reactivity Human

Source Tobacco (Nicotiana benthamiana)

Validations

Cat. No. ABIN1019696

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (His tag)

Reactivity Mouse

Source Human Cells

Validations

Cat. No. ABIN7320572

Quantity 50 μg

Datasheet Datasheet

IL12B Protein (AA 229-328) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1307678

Quantity 10 μg

Datasheet Datasheet

IL12B Protein (His tag)

Reactivity Human

Source Hi-5 Cells

Validations

Cat. No. ABIN1098598

Quantity 50 μg

Datasheet Datasheet

IL12B Protein (AA 23-328) (Fc Tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2181332

Quantity 50 μg

Datasheet Datasheet

IL12B Protein (AA 23-328) (His tag)

Reactivity Human

Source HEK-293 Cells

Validations

Cat. No. ABIN2181334

Quantity 50 μg

Datasheet Datasheet

IL12B Protein (AA 23-328, full length) (GST tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN1047232

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (AA 23-327, full length) (His tag)

Reactivity Sheep

Source Yeast

Validations

Cat. No. ABIN7479103

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (AA 1-335)

Reactivity Mouse

Source HEK-293 Cells

Validations

Cat. No. ABIN7505723

Quantity 100 μg

Datasheet Datasheet

IL12B Protein (AA 23-328) (His tag)

Reactivity Human

Source Escherichia coli (E. coli)

Validations

Cat. No. ABIN1000983

Quantity 10 μg

Datasheet Datasheet

IL12B Protein (AA 23-328)

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN4371190

Quantity 50 μg

Datasheet Datasheet

IL12B Protein (AA 23-335) (His tag)

Reactivity Mouse

Source Human Cells

Validations

Cat. No. ABIN4371797

Quantity 50 μg

Datasheet Datasheet

IL12B Protein

Reactivity Human

Source Human Cells

Validations

Cat. No. ABIN7318099

Quantity 50 μg

Datasheet Datasheet

Latest Publications for our IL12B Proteins

Wang, Li, Ge, Li, Wang, Gao, Qiu, Liu: "Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system." in: Nature immunology, Vol. 16, Issue 3, pp. 237-45, (2015) (PubMed).

Huang, Cancilla, Morahan: "Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit." in: Genes and immunity, Vol. 1, Issue 8, pp. 515-20, (2001) (PubMed).

Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, (1996) (PubMed).

Ling, Gately, Gubler, Stern, Lin, Hollfelder, Su, Pan, Hakimi: "Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 1, pp. 116-27, (1995) (PubMed).

DAndrea, Aste-Amezaga, Valiante, Ma, Kubin, Trinchieri: "Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1041-8, (1993) (PubMed).

DAndrea, Rengaraju, Valiante, Chehimi, Kubin, Aste, Chan, Kobayashi, Young, Nickbarg: "Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells." in: The Journal of experimental medicine, Vol. 176, Issue 5, pp. 1387-98, (1992) (PubMed).

Schoenhaut, Chua, Wolitzky, Quinn, Dwyer, McComas, Familletti, Gately, Gubler: "Cloning and expression of murine IL-12." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 148, Issue 11, pp. 3433-40, (1992) (PubMed).

Wolf, Temple, Kobayashi, Young, Dicig, Lowe, Dzialo, Fitz, Ferenz, Hewick: "Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 9, pp. 3074-81, (1991) (PubMed).

Gubler, Chua, Schoenhaut, Dwyer, McComas, Motyka, Nabavi, Wolitzky, Quinn, Familletti: "Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 10, pp. 4143-7, (1991) (PubMed).

Aliases for IL12B Proteins

interleukin 12B (IL12B) Proteins
interleukin 12b (Il12b) Proteins
interleukin 12B (Il12b) Proteins
interleukin 12Ba (il12ba) Proteins
CLMF Proteins
CLMF2 Proteins
CLMF p40 Proteins
IL-12 Proteins
IL-12 p40 Proteins
IL-12.p40 Proteins
IL-12B Proteins
Il-12b Proteins
Il-12p40 Proteins
IL-12p40 Proteins
Il12 Proteins
il12b Proteins
IL12B Proteins
Il12p40 Proteins
IL12p40 Proteins
il12p40.b Proteins
NKSF Proteins
NKSF2 Proteins
p40 Proteins
zgc:152789 Proteins

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IL12B Proteins by Origin

IL12B Proteins by Source

IL12B Proteins by Protein Type

IL12B Proteins by Application

IL12B Proteins by Biological Activity

Popular IL12B Proteins

Latest Publications for our IL12B Proteins

Aliases for IL12B Proteins

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