IL12B Products
(Interleukin 12 beta (IL12B))
Categories
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
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Featured IL12B Categories
IL12B Antibodies
High quality antibodies with extensive validation data.
IL12B ELISA Kits
Reliable ELISA kits for a wide range of species.
IL12B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IL12B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7428812
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Sheep
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7179323
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7156785
Quantity
100 μg
Datasheet
Datasheet
Recommended IL12B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957015
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957017
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Horse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957011
Quantity
96 tests
Datasheet
Datasheet
Recommended IL12B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (4)
Cat. No.
ABIN7275396
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Cynomolgus
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7275395
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana benthamiana)
Validations
- (2)
Cat. No.
ABIN1019696
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our IL12B products
: "Effects of Early Intervention with Antibiotics and Maternal Fecal Microbiota on Transcriptomic Profiling Ileal Mucusa in Neonatal Pigs." in: Antibiotics (Basel, Switzerland), Vol. 9, Issue 1, (2020) (PubMed).: "High-dose dexamethasone induced LPS-stimulated rat alveolar macrophages apoptosis." in: Drug design, development and therapy, Vol. 11, pp. 3097-3104, (2018) (PubMed).
: "VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism." in: Nature communications, Vol. 8, Issue 1, pp. 1322, (2018) (PubMed).
: "Pathway analysis of global gene expression change in dendritic cells induced by the polysaccharide from the roots of Actinidia eriantha." in: Journal of ethnopharmacology, Vol. 214, pp. 141-152, (2018) (PubMed).
: "Immunostimulatory activity of water-extractable polysaccharides from Cistanche deserticola as a plant adjuvant in vitro and in vivo." in: PLoS ONE, Vol. 13, Issue 1, pp. e0191356, (2018) (PubMed).
: "High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. ..." in: Cell metabolism, Vol. 25, Issue 1, pp. 197-207, (2017) (PubMed).
: "Preoperative Serum IL-12p40 Is a Potential Predictor of Kasai Portoenterostomy Outcome in Infants with Biliary Atresia." in: Gastroenterology research and practice, Vol. 2017, pp. 9089068, (2017) (PubMed).
: "Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells." in: Molecules (Basel, Switzerland), Vol. 22, Issue 1, (2017) (PubMed).
: "Serum Proteomics Analysis in Rats of Immunosuppression Induced by Chronic Stress." in: Scandinavian journal of immunology, Vol. 84, Issue 3, pp. 165-73, (2016) (PubMed).
: "Fusion cytokine IL-2-GMCSF enhances anticancer immune responses through promoting cell-cell interactions." in: Journal of translational medicine, Vol. 14, pp. 41, (2016) (PubMed).
Synonyms and alternative names related to IL12B
interleukin 12B (IL12B), interleukin 12b (Il12b), interleukin 12B (Il12b), interleukin 12Ba (il12ba), CLMF, CLMF2, CLMF p40, IL-12, IL-12 p40, IL-12.p40, IL-12B, Il-12b, Il-12p40, IL-12p40, Il12, il12b, IL12B, Il12p40, IL12p40, il12p40.b, NKSF, NKSF2, p40, zgc:152789Protein level used designations for IL12B
- CLMF p40
- IL-12 subunit p40
- IL12, subunit p40
- NK cell stimulatory factor chain 2
- cytotoxic lymphocyte maturation factor 40 kDa subunit
- interleukin 12, p40
- interleukin-12 beta chain
- interleukin-12 subunit beta
- natural killer cell stimulatory factor, 40 kD subunit
- IL-12 p40
- IL-23 subunit p40
- interleukin-12 p40
- IL-12B
- interleukin-12 p40 subunit
- IL-12 p40 subunit
- interleukin-12p40
- il-12p40.a
- interleukin 12 p40.b
- interleukin 12B
- interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- interleukin 12Ba (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
- interleukin 12 p40 subunit
- interleukin-12 p40 chain
- interleukin 12 40kDa subunit
- Cytotoxic lymphocyte maturation factor 40 kDa subunit
- Interleukin-12 subunit beta
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