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IL-37 Products

(Interleukin 37 (IL37))
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Featured IL-37 Categories

IL-37 Antibodies

High quality antibodies with extensive validation data.

IL-37 ELISA Kits

Reliable ELISA kits for a wide range of species.

IL-37 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IL-37 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ELISA, IP
Validations
  • (4)
Cat. No. ABIN1169178
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
Cat. No. ABIN565352
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7156912
Quantity 100 μL
Datasheet Datasheet

Recommended IL-37 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6957139
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6962627
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN2859232
Quantity 96 tests
Datasheet Datasheet

Recommended IL-37 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1307749
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN5509527
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN5564493
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our IL-37 products

Zhang, Zhu, Li, He, Zhang, Huang, Zhang, Li, Chang, Li: "Plasma Interleukin-37 is Elevated in Acute Ischemic Stroke Patients and Probably Associated With 3-month Functional Prognosis." in: Clinical interventions in aging, Vol. 15, pp. 1285-1294, (2020) (PubMed).

Ragab, Mobasher, Shabaan: "Elevated levels of IL-37 correlate with T cell activation status in rheumatoid arthritis patients." in: Cytokine, Vol. 113, pp. 305-310, (2019) (PubMed).

DAngelo, Reale, Costantini, Di Nicola, Porfilio, de Andrés, Fernández-Paredes, Sánchez-Ramón, Pasquali: "Profiling of Canonical and Non-Traditional Cytokine Levels in Interferon-β-Treated Relapsing-Remitting-Multiple Sclerosis Patients." in: Frontiers in immunology, Vol. 9, pp. 1240, (2018) (PubMed).

Tawfik, Nasef, Omar, Ghaly: "Serum Interleukin-37: a new player in Lupus Nephritis?" in: International journal of rheumatic diseases, Vol. 20, Issue 8, pp. 996-1001, (2018) (PubMed).

Yang, Fang, Chen, Ma, Xiao, Zou, Zheng, Yan, Liao, Chen, Fang, Yu, Liu, Dong: "Elevated plasma interleukin-37 playing an important role in acute coronary syndrome through suppression of ROCK activation." in: Oncotarget, Vol. 8, Issue 6, pp. 9686-9695, (2018) (PubMed).

Jiang, Wang, Zhang, Ji, Zhao, Sun, Zhang: "IL-37 inhibits invasion and metastasis in non-small cell lung cancer by suppressing the IL-6/STAT3 signaling pathway." in: Thoracic cancer, Vol. 9, Issue 5, pp. 621-629, (2018) (PubMed).

Günaltay, Ghiboub, Hultgren, Hörnquist: "Reduced IL-37 Production Increases Spontaneous Chemokine Expressions in Colon Epithelial Cells." in: Digestive diseases and sciences, Vol. 62, Issue 5, pp. 1204-1215, (2017) (PubMed).

Liu, Xue, Zhu, Xuan, Yang, Liang, Wang, Zhu, Zhang, Zou: "Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout." in: Arthritis research & therapy, Vol. 18, Issue 1, pp. 268, (2016) (PubMed).

Huang, Gao, Chi, Hu, Zheng, Zeng, Wang: "IL-37 expression is upregulated in patients with tuberculosis and induces macrophages towards an M2-like phenotype." in: Scandinavian journal of immunology, (2015) (PubMed).

Huang, Zhao, Gao, Chi, Zeng, Hu, Zheng, Wang: "Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces IL-37 production via upregulating ERK1/2 and p38 in human type II alveolar epithelial cells." in: International journal of clinical and experimental medicine, Vol. 8, Issue 5, pp. 7279-87, (2015) (PubMed).

Synonyms and alternative names related to IL-37

interleukin 37 (IL37), FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H, IL-1H4, IL-1RP1, IL-37, IL1F7, IL1H4, IL1RP1

Protein level used designations for IL-37

  • FIL1 zeta
  • IL-1 zeta
  • IL-1F7b (IL-1H4, IL-1H, IL-1RP1)
  • IL-1X protein
  • IL1F7 (canonical product IL-1F7b)
  • interleukin 1 family member 7
  • interleukin 1, zeta
  • interleukin-1 homolog 4
  • interleukin-1 superfamily z
  • interleukin-1-related protein
  • interleukin-23
  • interleukin-37
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