IKZF3 Products
(IKAROS Family Zinc Finger 3 (Aiolos) (IKZF3))
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This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012].
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Featured IKZF3 Categories
IKZF3 Antibodies
High quality antibodies with extensive validation data.
IKZF3 ELISA Kits
Reliable ELISA kits for a wide range of species.
IKZF3 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IKZF3 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IHC, IF
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- (7)
Cat. No.
ABIN7267842
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (1)
- (2)
Cat. No.
ABIN564938
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
Cat. No.
ABIN524769
Quantity
50 μg
Datasheet
Datasheet
Recommended IKZF3 ELISA Kits
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6975069
Quantity
96 tests
Datasheet
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Reactivity
Source
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Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307656
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3081893
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
Cat. No.
ABIN3131337
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our IKZF3 products
: "Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4." in: Blood cancer journal, Vol. 9, Issue 2, pp. 19, (2019) (PubMed).: "Potent antitumor effect of combination therapy with sub-optimal doses of Akt inhibitors and pomalidomide plus dexamethasone in multiple myeloma." in: Oncology letters, Vol. 15, Issue 6, pp. 9450-9456, (2018) (PubMed).
: "p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 14, pp. 3565-3571, (2017) (PubMed).
: "Activation of c-Abl Kinase Potentiates the Anti-myeloma Drug Lenalidomide by Promoting DDA1 Protein Recruitment to the CRL4 Ubiquitin Ligase." in: The Journal of biological chemistry, Vol. 292, Issue 9, pp. 3683-3691, (2017) (PubMed).
: "Selective degradation of splicing factor CAPERα by anticancer sulfonamides." in: Nature chemical biology, Vol. 13, Issue 6, pp. 675-680, (2017) (PubMed).
: "Lenalidomide increases human dendritic cell maturation in multiple myeloma patients targeting monocyte differentiation and modulating mesenchymal stromal cell inhibitory properties." in: Oncotarget, Vol. 8, Issue 32, pp. 53053-53067, (2017) (PubMed).
: "Identification of cereblon-binding proteins and relationship with response and survival after IMiDs in multiple myeloma." in: Blood, Vol. 124, Issue 4, pp. 536-45, (2014) (PubMed).
: "Ikaros family transcription factors in chronic and acute leukemia." in: American journal of hematology, Vol. 84, Issue 6, pp. 375-7, (2009) (PubMed).
: "Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits." in: Immunity, Vol. 26, Issue 3, pp. 335-44, (2007) (PubMed).
Synonyms and alternative names related to IKZF3
IKAROS family zinc finger 3 (IKZF3), IKAROS family zinc finger 3 L homeolog (ikzf3.L), IKAROS family zinc finger 3 (Ikzf3), 5830411O07Rik, AIO, aio, AIOLOS, aiolos, Aiolos, IKZF3, Zfpn1a3, ZNFN1A3, znfn1a3, Znfn1a3Protein level used designations for IKZF3
- zinc finger protein Aiolos
- zinc finger protein, subfamily 1A, 3 (Aiolos)
- lymphoid transcription factor
- IKAROS family zinc finger 3 (Aiolos)
- ikaros family zinc finger protein 3
- zinc finger protein Aiolos-like
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