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IKBKG Products

(Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011].

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Featured IKBKG Categories

IKBKG Antibodies

High quality antibodies with extensive validation data.

IKBKG ELISA Kits

Reliable ELISA kits for a wide range of species.

IKBKG Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended IKBKG Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (2)
  • (7)
Cat. No. ABIN3021151
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF, IHC (p), PLA
Validations
  • (6)
Cat. No. ABIN563664
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (5)
Cat. No. ABIN7189515
Quantity 100 μg
Datasheet Datasheet

Recommended IKBKG ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN6967600
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6956745
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN1380483
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended IKBKG Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123431
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123432
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123433
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our IKBKG products

Sakowicz, Lisowska, Biesiada, Płuciennik, Gach, Rybak-Krzyszkowska, Huras, Sakowicz, Romanowicz, Piastowska-Ciesielska, Grzesiak, Pietrucha: "Placental Expression of NEMO Protein in Normal Pregnancy and Preeclampsia." in: Disease markers, Vol. 2019, pp. 8418379, (2019) (PubMed).

Alameda, Ramírez, García-Fernández, Navarro, Page, Segovia, Sanchez, Suárez-Cabrera, Paramio, Bravo, Fernández-Aceñero, Casanova: "Premature aging and cancer development in transgenic mice lacking functional CYLD." in: Aging, Vol. 11, Issue 1, pp. 127-159, (2019) (PubMed).

Zhu, Fang, Wang, Yang, Chen, Ye, Foda, Xiao: "Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO." in: Virology, Vol. 502, pp. 33-38, (2017) (PubMed).

Zhou, Yu, Demirkaya, Deuitch, Stone, Tsai, Kuehn, Wang, Yang, Park, Ombrello, Blake, Romeo, Remmers, Chae, Mullikin, Güzel, Milner, Boehm, Rosenzweig, Gadina, Welch, Özen, Topaloglu, Abinun, Kastner et al.: "Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 36, pp. 10127-32, (2016) (PubMed).

Guo, Hu, Chen, Li, Ye, Cheng, Zhang, He: "iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus." in: Journal of proteomics, Vol. 130, pp. 65-75, (2016) (PubMed).

Ren, Takahashi, Liu, Loughran, Sun, Wang, Cheng: "HTLV-1 Tax deregulates autophagy by recruiting autophagic molecules into lipid raft microdomains." in: Oncogene, Vol. 34, Issue 3, pp. 334-45, (2015) (PubMed).

Konrath, Witt, Sauter, Kulms: "Identification of new IκBα complexes by an iterative experimental and mathematical modeling approach." in: PLoS computational biology, Vol. 10, Issue 3, pp. e1003528, (2014) (PubMed).

Wang, Fang, Wei, Zhang, Luo, Chen, Li, Xiao: "Hepatitis A virus 3C protease cleaves NEMO to impair induction of beta interferon." in: Journal of virology, Vol. 88, Issue 17, pp. 10252-8, (2014) (PubMed).

Fusco, DUrso, Miano, Ursini: "The LCR at the IKBKG locus is prone to recombine." in: American journal of human genetics, Vol. 86, Issue 4, pp. 650-2; author reply 652-3, (2010) (PubMed).

Hsiao, Lin, Chiang, Wu, Chen, Lin: "NEMO gene mutations in Chinese patients with incontinentia pigmenti." in: Journal of the Formosan Medical Association = Taiwan yi zhi, Vol. 109, Issue 3, pp. 192-200, (2010) (PubMed).

Synonyms and alternative names related to IKBKG

inhibitor of nuclear factor kappa B kinase subunit gamma (IKBKG), inhibitor of kappaB kinase gamma (Ikbkg), inhibitor of nuclear factor kappa B kinase subunit gamma (Ikbkg), inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (ikbkg), inhibitor of nuclear factor kappa B kinase subunit gamma L homeolog (ikbkg.L), inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG), inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma (IKBKG_1), inhibitor of nuclear factor kappa B kinase subunit gamma (ikbkg), kenny (key), 1110037D23Rik, AI848108, AI851264, AMCBX1, AW124339, CG16910, dIKK, dIKK-gamma, Dmel\\CG16910, DmIKK-gamma, DmIKKgamma, Dmikkgamma, dmIKKgamma, FIP-3, FIP3, Fip3p, fj33c07, IKBKG, IKBKG_1, IKBKG_2, IKK, IKK-gamma, IKKg, IKKgamma, IKK[g], IKK[[gamma]], IP, IP1, IP2, IPD2, Kenny, KEY, Key, MGC97885, NEMO, Nemo, nemo, wu:fj33c07, ZC2HC9, zgc:113492

Protein level used designations for IKBKG

  • I-kappa-B kinase subunit gamma
  • IKKAP1
  • IKKG
  • IkB kinase gamma subunit
  • NF-kappa-B essential modifier
  • NF-kappa-B essential modulator
  • NFkappaB essential modulator
  • ikB kinase subunit gamma
  • ikB kinase-associated protein 1
  • incontinentia pigmenti
  • inhibitor of nuclear factor kappa-B kinase subunit gamma
  • IKK-gamma
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
  • mFIP-3
  • I-kappa-B kinase gamma
  • NEMO
  • NF-kappa B essential modulator
  • inhibitor of kappaB kinase gamma
  • ikky
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 1
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma, isoform 2
  • NF-kappa-B essential modulator-like
  • CG16910-PA
  • CG16910-PB
  • key-PA
  • key-PB
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