IGKV1-27 Products
(Immunoglobulin kappa Variable 1-27 (IGKV1-27))
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This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012].
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IGKV1-27 Antibodies
High quality antibodies with extensive validation data.
Recommended IGKV1-27 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, IF, ELISA
Validations
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Cat. No.
ABIN3183105
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC, IC
Validations
- (3)
Cat. No.
ABIN7297166
Quantity
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Datasheet
Datasheet
Reactivity
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Application
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Validations
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Cat. No.
ABIN6282844
Quantity
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Datasheet
Datasheet
Latest Publications for our IGKV1-27 products
: "The promyelocytic leukemia protein represses A20-mediated transcription." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 31734-9, (2002) (PubMed).: "TNF-induced mitochondrial changes and activation of apoptotic proteases are inhibited by A20." in: Free radical biology & medicine, Vol. 25, Issue 1, pp. 57-65, (1999) (PubMed).
: "Lymphoid expression and regulation of A20, an inhibitor of programmed cell death." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1699-706, (1995) (PubMed).
: "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin." in: The Journal of biological chemistry, Vol. 265, Issue 5, pp. 2973-8, (1990) (PubMed).
: "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein." in: The Journal of biological chemistry, Vol. 265, Issue 25, pp. 14705-8, (1990) (PubMed).
Synonyms and alternative names related to IGKV1-27
TNF alpha induced protein 3 (TNFAIP3), A20, OTUD7C, TNFA1P2Protein level used designations for IGKV1-27
- OTU domain-containing protein 7C
- TNF alpha-induced protein 3
- putative DNA-binding protein A20
- tumor necrosis factor alpha-induced protein 3
- tumor necrosis factor inducible protein A20
- zinc finger protein A20
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