IDH1 Products
(Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))
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Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
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Featured IDH1 Categories
IDH1 Antibodies
High quality antibodies with extensive validation data.
IDH1 ELISA Kits
Reliable ELISA kits for a wide range of species.
IDH1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended IDH1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (8)
Cat. No.
ABIN3023106
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (10)
Cat. No.
ABIN7436579
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, FACS, IF, IHC (p)
Validations
- (7)
Cat. No.
ABIN391660
Quantity
400 μL
Datasheet
Datasheet
Recommended IDH1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (2)
Cat. No.
ABIN6574327
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957223
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN581788
Quantity
96 tests
Datasheet
Datasheet
Recommended IDH1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
Cat. No.
ABIN7274843
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123639
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123640
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our IDH1 products
: "Serological Biomarkers for Early Detection of Hepatocellular Carcinoma: A Focus on Autoantibodies against Tumor-Associated Antigens Encoded by Cancer Driver Genes." in: Cancers, Vol. 12, Issue 5, (2020) (PubMed).: "IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer." in: Molecular oncology, Vol. 12, Issue 5, pp. 602-610, (2019) (PubMed).
: "lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma." in: International journal of oncology, Vol. 53, Issue 2, pp. 551-566, (2018) (PubMed).
: "AMP-Activated Protein Kinase α2 in Neutrophils Regulates Vascular Repair via Hypoxia-Inducible Factor-1α and a Network of Proteins Affecting Metabolism and Apoptosis." in: Circulation research, Vol. 120, Issue 1, pp. 99-109, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." in: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "DIGE based proteome analysis of mammary gland tissue in water buffalo (Bubalus bubalis): Lactating vis-a-vis heifer." in: Journal of proteomics, Vol. 119C, pp. 100-111, (2015) (PubMed).
: "The effects of PGC-1α on the proliferation and energy metabolism of malignant endometrial cancer cells." in: OncoTargets and therapy, Vol. 8, pp. 769-74, (2015) (PubMed).
: "Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma." in: Acta neuropathologica communications, Vol. 3, pp. 4, (2015) (PubMed).
: "A high-throughput fluorimetric assay for 2-hydroxyglutarate identifies Zaprinast as a glutaminase inhibitor." in: Cancer discovery, Vol. 4, Issue 7, pp. 828-39, (2014) (PubMed).
: "IDH1 regulates phospholipid metabolism in developing astrocytes." in: Neuroscience letters, Vol. 582, pp. 87-92, (2014) (PubMed).
Synonyms and alternative names related to IDH1
isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1), isocitrate dehydrogenase 1 (NADP+), soluble (Idh1), isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1), isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L), isocitrate dehydrogenase 1 (NADP+), soluble (idh1), isocitrate dehydrogenase 1 (IDH1), AI314845, AI788952, cb876, E030024J03Rik, F23E12.180, F23E12_180, fm90e09, Id-1, IDCD, IDH, Idh-1, IDH-I, IDP, IDPC, Idpc, im:7143416, isocitrate dehydrogenase 1, isocitrate dehydrogenase I, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 1, NADP-CICDH, PICD, wu:fm90e09Protein level used designations for IDH1
- NADP(+)-specific ICDH
- NADP-dependent isocitrate dehydrogenase, cytosolic
- NADP-dependent isocitrate dehydrogenase, peroxisomal
- isocitrate dehydrogenase [NADP] cytoplasmic
- oxalosuccinate decarboxylase
- IDH
- IDP
- cytosolic NADP-isocitrate dehydrogenase
- isocitrate dehydrogenase 1 (NADP+), soluble
- isocitrate dehydrogenase [NADP] cytoplasmic-like
- Isocitrate dehydrogenase 1, soluble
- isocitrate dehydrogenase 1
- IDH-I
- Isocitric dehydrogenase 1
- NAD(+)-specific ICDH 1
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