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HYAL2 Products

(Hyaluronidase-2 (HYAL2))
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.[provided by RefSeq, Mar 2010].

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Featured HYAL2 Categories

HYAL2 Antibodies

High quality antibodies with extensive validation data.

HYAL2 ELISA Kits

Reliable ELISA kits for a wide range of species.

HYAL2 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HYAL2 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (3)
Cat. No. ABIN654687
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (2)
Cat. No. ABIN7155971
Quantity 100 μL
Datasheet Datasheet
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (2)
Cat. No. ABIN7436957
Quantity 100 μL
Datasheet Datasheet

Recommended HYAL2 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967482
Quantity 96 tests
Datasheet Datasheet
Reactivity Sheep
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6967483
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN581358
Quantity 96 tests
Datasheet Datasheet

Recommended HYAL2 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7123374
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1307302
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN7504422
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our HYAL2 products

Kong, Ordoñez, Turner, Tremaine, Muter, Lucas, Salisbury, Vassena, Tiscornia, Fouladi-Nashta, Hartshorne, Brosens, Brighton: "Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 4, pp. e21336, (2021) (PubMed).

Panogeorgou, Tserbini, Filou, Vynios, Naxakis, Papadas, Goumas, Mastronikolis: "Hyaluronan synthases and hyaluronidases in nasal polyps." in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, Vol. 273, Issue 7, pp. 1801-8, (2016) (PubMed).

Monzon, Fregien, Schmid, Falcon, Campos, Casalino-Matsuda, Forteza: "Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation." in: The Journal of biological chemistry, Vol. 285, Issue 34, pp. 26126-34, (2010) (PubMed).

Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: "Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 3, pp. 289-95, (2008) (PubMed).

Synonyms and alternative names related to HYAL2

hyaluronoglucosaminidase 2 S homeolog (hyal2.S), hyaluronoglucosaminidase 2 (HYAL2), hyaluronoglucosaminidase 2b (hyal2b), hyaluronoglucosaminidase 2 (hyal2), hyaluronoglucosaminidase 2 L homeolog (hyal2.L), hyaluronoglucosaminidase 2 (Hyal2), AI256841, AU020858, AW555733, hyal2, hyal2a, hyal2b, luca-2, luca2, LUCA2, oHyal2, si:dkey-42i9.14, xhyal2

Protein level used designations for HYAL2

  • hyaluronidase 2 b
  • hyaluronoglucosaminidase 2
  • hyaluronidase-2
  • hyaluronidase 2
  • hyaluronidase 2 a
  • hyaluronidase-2-like
  • PH-20 homolog
  • PH20 homolog
  • hyal-2
  • hyaluronoglucosaminidase-2
  • lung carcinoma protein 2
  • lysosomal hyaluronidase
  • GPI-anchored surface protein
  • JSRV envelope protein receptor
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