HUWE1 Products
(HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
Categories
This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type. [provided by RefSeq, Nov 2009].
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Featured HUWE1 Categories
HUWE1 Antibodies
High quality antibodies with extensive validation data.
HUWE1 ELISA Kits
Reliable ELISA kits for a wide range of species.
HUWE1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HUWE1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN213933
Quantity
0.05 mg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7248203
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN564354
Quantity
50 μL
Datasheet
Datasheet
Recommended HUWE1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967324
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967325
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967323
Quantity
96 tests
Datasheet
Datasheet
Recommended HUWE1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307296
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our HUWE1 products
: "Infection with flaviviruses requires BCLXL for cell survival." in: PLoS pathogens, Vol. 14, Issue 9, pp. e1007299, (2019) (PubMed).: "Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation." in: Molecular & cellular proteomics : MCP, Vol. 16, Issue 4 suppl 1, pp. S200-S214, (2017) (PubMed).
: "Destabilization of Atoh1 by E3 Ubiquitin Ligase Huwe1 and Casein Kinase 1 Is Essential for Normal Sensory Hair Cell Development." in: The Journal of biological chemistry, Vol. 291, Issue 40, pp. 21096-21109, (2016) (PubMed).
: "HUWE1 interacts with PCNA to alleviate replication stress." in: EMBO reports, Vol. 17, Issue 6, pp. 874-86, (2016) (PubMed).
: "The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets." in: Molecular & cellular proteomics : MCP, Vol. 13, Issue 12, pp. 3585-601, (2014) (PubMed).
: "Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice." in: The Journal of biological chemistry, Vol. 287, Issue 7, pp. 5102-11, (2012) (PubMed).
: "Regulation of oxidative DNA damage repair by DNA polymerase λ and MutYH by cross-talk of phosphorylation and ubiquitination." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 2, pp. 437-42, (2012) (PubMed).
: "Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis." in: Journal of neuroimmunology, Vol. 244, Issue 1-2, pp. 51-6, (2012) (PubMed).
: "HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation." in: Biochemical and biophysical research communications, Vol. 418, Issue 2, pp. 408-13, (2012) (PubMed).
: "The double life of MULE in preeclamptic and IUGR placentae." in: Cell death & disease, Vol. 3, pp. e305, (2012) (PubMed).
Synonyms and alternative names related to HUWE1
HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1), HECT, UBA and WWE domain containing 1 (Huwe1), HECT, UBA and WWE domain containing 1 (huwe1), HECT, UBA and WWE domain containing 1 (LOC100123214), HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (huwe1), E3 ubiquitin-protein ligase HUWE1 (LOC100380641), HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1), 5430439H10Rik, ARF-BP1, Arf-bp1, arf-bp1, AU041296, C80292, C430014N20Rik, Gm1718, HECTH9, hecth9, HSPC272, hspc272, HUWE1, Huwe1, Ib772, ib772, LASU1, lasu1, MULE, Mule, mule, si:dkey-242a8.2, URE-B1, UREB1, Ureb1, ureb1Protein level used designations for HUWE1
- ARF-binding protein 1
- BJ-HCC-24 tumor antigen
- E3 ubiquitin-protein ligase HUWE1
- HECT domain protein LASU1
- Mcl-1 ubiquitin ligase E3
- URE-binding protein 1
- homologous to E6AP carboxyl terminus homologous protein 9
- large structure of UREB1
- upstream regulatory element-binding protein 1
- E3Histone
- HECT, UBA and WWE domain-containing protein 1
- Mcl-1 ubiquitin ligase
- URE-B1
- upstream regulatory element binding protein 1
- HECT, UBA and WWE domain containing 1
- rp3-339a18.4
- e3 ubiquitin-protein ligase HUWE1-like
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