HTR2C Products
(5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))
Categories
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012].
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Featured HTR2C Categories
HTR2C Antibodies
High quality antibodies with extensive validation data.
HTR2C ELISA Kits
Reliable ELISA kits for a wide range of species.
HTR2C Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HTR2C Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB
Validations
- (6)
Cat. No.
ABIN2792274
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6257909
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IHC (p)
Validations
- (3)
Cat. No.
ABIN574008
Quantity
50 μL
Datasheet
Datasheet
Recommended HTR2C ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953364
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5674799
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5674800
Quantity
96 tests
Datasheet
Datasheet
Recommended HTR2C Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7121620
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307274
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7397540
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HTR2C products
: "Alcohol drives S-nitrosylation and redox activation of protein phosphatase 1, causing bovine airway cilia dysfunction." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 312, Issue 3, pp. L432-L439, (2017) (PubMed).: "An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models." in: ACS chemical neuroscience, Vol. 6, Issue 7, pp. 1259-70, (2015) (PubMed).
: "Involvement of spinal serotonin receptors in electroacupuncture anti-hyperalgesia in an inflammatory pain rat model." in: Neurochemical research, Vol. 36, Issue 10, pp. 1785-92, (2011) (PubMed).
: "Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling." in: Frontiers in cellular neuroscience, Vol. 4, pp. 132, (2011) (PubMed).
: "Complex seizure disorder caused by Brunol4 deficiency in mice." in: PLoS genetics, Vol. 3, Issue 7, pp. e124, (2007) (PubMed).
: "Serotonin receptor 2C (HTR2C) and schizophrenia: examination of possible medication and genetic influences on expression levels." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 134B, Issue 1, pp. 84-9, (2005) (PubMed).
: "5-Hydroxytryptamine2C receptors on pudendal motoneurons innervating the external anal sphincter." in: Brain research, Vol. 1057, Issue 1-2, pp. 65-71, (2005) (PubMed).
Synonyms and alternative names related to HTR2C
5-hydroxytryptamine receptor 2C (HTR2C), 5-hydroxytryptamine (serotonin) receptor 2C (Htr2c), 5-hydroxytryptamine receptor 2C (Htr2c), 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled S homeolog (htr2c.S), 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled-like 1 (htr2cl1), 5-hydroxytryptamine receptor 2C (LOC407134), 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled (HTR2C), 5-HT-2C, 5-HT2C, 5-HT2cR, 5-ht2cr, 5-HTR2C, 5HT-1C, 5HT1c, 5HT2C, 5ht2c, 5HTR2C, HTR1C, Htr1c, si:dkey-24g18.2, SR1Protein level used designations for HTR2C
- 5-HT-1C
- 5-HT-2C
- 5-HT1C
- 5-hydroxytryptamine receptor 1C
- 5-hydroxytryptamine receptor 2C
- 5-hydroxytryptamine receptor-1c
- serotonin 5-HT-2C receptor
- serotonin receptor 2C
- 5-HT2C receptor
- serotonin 1c receptor
- 5-hydroxytryptamine (serotonin) receptor 2C
- 5HT2C serotonin receptor
- 5-HT2C
- 5-alpha-hydroxytryptamine receptor 2C
- 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
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