HRPT2 Products
(Parafibromin (CDC73))
Categories
This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009].
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Featured HRPT2 Categories
HRPT2 Antibodies
High quality antibodies with extensive validation data.
HRPT2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HRPT2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (7)
Cat. No.
ABIN653128
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (1)
Cat. No.
ABIN6243752
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IF
Validations
- (1)
Cat. No.
ABIN7162615
Quantity
100 μg
Datasheet
Datasheet
Recommended HRPT2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6229403
Quantity
96 tests
Datasheet
Datasheet
Recommended HRPT2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124308
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348869
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2728223
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our HRPT2 products
: "Histone H3R17me2a mark recruits human RNA polymerase-associated factor 1 complex to activate transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 15, pp. 5675-80, (2012) (PubMed).: "A role for the RNA pol II-associated PAF complex in AID-induced immune diversification." in: The Journal of experimental medicine, Vol. 209, Issue 11, pp. 2099-111, (2012) (PubMed).
: "The tumor suppressor, parafibromin, mediates histone H3 K9 methylation for cyclin D1 repression." in: Nucleic acids research, Vol. 38, Issue 2, pp. 382-90, (2010) (PubMed).
: "The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs." in: Nucleic acids research, Vol. 38, Issue 21, pp. 7637-50, (2010) (PubMed).
: "The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 3, pp. 755-60, (2009) (PubMed).
: "Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice." in: Molecular and cellular biology, Vol. 28, Issue 9, pp. 2930-40, (2008) (PubMed).
: "The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 45, pp. 17420-5, (2008) (PubMed).
: "Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains." in: Genes & development, Vol. 22, Issue 4, pp. 528-42, (2008) (PubMed).
: "Parafibromin immunoreactivity: its use as an additional diagnostic marker for parathyroid tumor classification." in: Endocrine-related cancer, Vol. 14, Issue 2, pp. 501-12, (2007) (PubMed).
: "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo." in: Cell, Vol. 125, Issue 2, pp. 327-41, (2006) (PubMed).
Synonyms and alternative names related to HRPT2
cell division cycle 73 (CDC73), cell division cycle 73, Paf1/RNA polymerase II complex component (Cdc73), cell division cycle 73 (Cdc73), cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) (cdc73), cell division cycle 73 (cdc73), parafibromin (Tsp_03925), parafibromin (Tsp_04052), parafibromin (Tsp_04125), cell division cycle 73 S homeolog (cdc73.S), 8430414L16Rik, BC027756, C1orf28, C81219, C130030P16Rik, cdc73, HPTJT, HRPT2, Hrpt2, hrpt2, HYX, LOC100222932, MGC108428, zgc:63956Protein level used designations for HRPT2
- Paf1/RNA polymerase II complex component
- cell division cycle 73, Paf1/RNA polymerase II complex component, homolog
- cell division cycle protein 73 homolog
- hyperparathyroidism 2 protein
- parafibromin
- Vcell division cycle 73, Paf1/RNA polymerase II complex component, homolog
- hyperparathyroidism 2 homolog
- hyperparathyroidism 2 protein homolog
- hyperparathyroidism 2 (with jaw tumor)
- sun
- sunrise
- hyperparathyroidism 2 with jaw tumor protein
- Parafibromin
- cell division cycle 73 S homeolog
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