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HRG Products

(Histidine-Rich Glycoprotein (HRG))

Categories

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels. [provided by RefSeq, Jul 2008].

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Featured HRG Categories

HRG Antibodies

High quality antibodies with extensive validation data.

HRG ELISA Kits

Reliable ELISA kits for a wide range of species.

HRG Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HRG Antibodies

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Reactivity
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Cat. No.
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Reactivity Rat
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Cat. No. ABIN7427567
Quantity 100 μL
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Cat. No. ABIN7440872
Quantity 100 μL
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Cat. No. ABIN7434977
Quantity 100 μL
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Recommended HRG ELISA Kits

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Reactivity
Analytical Method
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Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
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Cat. No. ABIN6720587
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6956556
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6967423
Quantity 96 tests
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Recommended HRG Proteins

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Cat. No. ABIN1307066
Quantity 25 μg
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Source HEK-293 Cells
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Cat. No. ABIN7504420
Quantity 100 μg
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Reactivity Mouse
Source Escherichia coli (E. coli)
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Cat. No. ABIN7413226
Quantity 100 μg
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Latest Publications for our HRG products

Mattii, Bianchi, Falleni, Frascarelli, Masini, Alì, Chiellini, Sabbatini: "Ultrastructural Localization of Histidine-rich Glycoprotein in Skeletal Muscle Fibers: Colocalization With AMP Deaminase." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 68, Issue 2, pp. 139-148, (2020) (PubMed).

Aksornphusitaphong, Phupong: "Combination of serum histidine-rich glycoprotein and uterine artery Doppler to predict preeclampsia." in: Hypertension research : official journal of the Japanese Society of Hypertension, Vol. 41, Issue 4, pp. 275-281, (2018) (PubMed).

Shemesh, Yu, Gaus, Seth, Swayze, Bennett, Geary, Henry, Wang: "Pharmacokinetic and Pharmacodynamic Investigations of ION-353382, a Model Antisense Oligonucleotide: Using Alpha-2-Macroglobulin and Murinoglobulin Double-Knockout Mice." in: Nucleic acid therapeutics, Vol. 26, Issue 4, pp. 223-35, (2016) (PubMed).

Deuschle, Birkel, Hambruch, Hornberger, Kinzel, Perovi?-Ottstadt, Schulz, Hahn, Burnet, Kremoser: "The nuclear bile acid receptor FXR controls the liver derived tumor suppressor histidine-rich glycoprotein." in: International journal of cancer. Journal international du cancer, Vol. 136, Issue 11, pp. 2693-704, (2015) (PubMed).

Glorieux, Mullen, Duranton, Filip, Gayrard, Husi, Schepers, Neirynck, Schanstra, Jankowski, Mischak, Argilés, Vanholder, Vlahou, Klein: "New insights in molecular mechanisms involved in chronic kidney disease using high-resolution plasma proteome analysis." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, (2015) (PubMed).

Matboli, Eissa, Said: "Evaluation of histidine-rich glycoprotein tissue RNA and serum protein as novel markers for breast cancer." in: Medical oncology (Northwood, London, England), Vol. 31, Issue 4, pp. 897, (2014) (PubMed).

Tugues, Roche, Noguer, Orlova, Bhoi, Padhan, Akerud, Honjo, Selvaraju, Mazzone, Tolmachev, Claesson-Welsh: "Histidine-rich glycoprotein uptake and turnover is mediated by mononuclear phagocytes." in: PLoS ONE, Vol. 9, Issue 9, pp. e107483, (2014) (PubMed).

Gu, Duce, Valova, Wong, Bush, Petrou, Wiley: "P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid." in: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17318-30, (2012) (PubMed).

Bolin, Wikström, Wiberg-Itzel, Olsson, Ringvall, Sundström-Poromaa, Axelsson, Thilaganathan, Åkerud: "Prediction of preeclampsia by combining serum histidine-rich glycoprotein and uterine artery Doppler." in: American journal of hypertension, Vol. 25, Issue 12, pp. 1305-10, (2012) (PubMed).

Wu, Xie, Liu, He, Benitez, Buckanovich, Lubman: "Identification and confirmation of differentially expressed fucosylated glycoproteins in the serum of ovarian cancer patients using a lectin array and LC-MS/MS." in: Journal of proteome research, Vol. 11, Issue 9, pp. 4541-52, (2012) (PubMed).

Synonyms and alternative names related to HRG

histidine rich glycoprotein (HRG), histidine-rich glycoprotein (LOAG_12427), histidine-rich glycoprotein (LOC100597044), histidine-rich glycoprotein (Hrg), AI265597, AW413091, D16jh2, D18020, Hprg, HPRG, HRG1, Hrgp, HRGP, THPH11

Protein level used designations for HRG

  • histidine-rich glycoprotein
  • histidine-proline-rich glycoprotein
  • histidine-rich glycoprotein 1
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