HRas proto-oncogene, GTPase Products
(HRas proto-oncogene, GTPase (HRAS))
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This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured HRas proto-oncogene, GTPase Categories
HRas proto-oncogene, GTPase Antibodies
High quality antibodies with extensive validation data.
HRas proto-oncogene, GTPase ELISA Kits
Reliable ELISA kits for a wide range of species.
HRas proto-oncogene, GTPase Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HRas proto-oncogene, GTPase Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC (p), ICC
Validations
- (4)
- (8)
Cat. No.
ABIN2857002
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN392183
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Dog, Human, Monkey, Mouse, Rat
Application
WB, IHC, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN1498713
Quantity
100 μL
Datasheet
Datasheet
Recommended HRas proto-oncogene, GTPase ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967463
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Goat
Analytical Method
Validations
Cat. No.
ABIN996714
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Dog
Analytical Method
Quantitative
Validations
Cat. No.
ABIN996715
Quantity
96 tests
Datasheet
Datasheet
Recommended HRas proto-oncogene, GTPase Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307056
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1307058
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7505275
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HRas proto-oncogene, GTPase products
: "Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets." in: Cancer research, Vol. 78, Issue 4, pp. 891-908, (2019) (PubMed).: "Mouse genetic background influences whether HrasG12V expression plus Cdkn2a knockdown causes angiosarcoma or undifferentiated pleomorphic sarcoma." in: Oncotarget, Vol. 9, Issue 28, pp. 19753-19766, (2018) (PubMed).
: "Nogo-B receptor increases the resistance to tamoxifen in estrogen receptor-positive breast cancer cells." in: Breast cancer research : BCR, Vol. 20, Issue 1, pp. 112, (2018) (PubMed).
: "Oncogenic HrasG12V expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma." in: PLoS ONE, Vol. 12, Issue 10, pp. e0186102, (2017) (PubMed).
: "Overexpression of DDX43 mediates MEK inhibitor resistance through RAS Upregulation in uveal melanoma cells." in: Molecular cancer therapeutics, Vol. 13, Issue 8, pp. 2073-80, (2014) (PubMed).
: "Mutational analysis of HRAS and KRAS genes in oral carcinoma cell lines." in: Odontology / the Society of the Nippon Dental University, Vol. 100, Issue 2, pp. 149-55, (2012) (PubMed).
: "Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome." in: Nature genetics, Vol. 44, Issue 7, pp. 783-7, (2012) (PubMed).
: "p66(Shc) restrains Ras hyperactivation and suppresses metastatic behavior." in: Oncogene, Vol. 29, Issue 41, pp. 5559-67, (2010) (PubMed).
: "The Hsp90 molecular chaperone: an open and shut case for treatment." in: The Biochemical journal, Vol. 410, Issue 3, pp. 439-53, (2008) (PubMed).
: "Expressed as the sole Hsp90 of yeast, the alpha and beta isoforms of human Hsp90 differ with regard to their capacities for activation of certain client proteins, whereas only Hsp90beta generates ..." in: The FEBS journal, Vol. 274, Issue 17, pp. 4453-63, (2007) (PubMed).
Synonyms and alternative names related to HRas proto-oncogene, GTPase
HRas proto-oncogene, GTPase (HRAS), v-Ha-ras Harvey rat sarcoma viral oncogene homolog a (hrasa), neuroblastoma RAS viral (v-ras) oncogene homolog pseudogene (LOC733587), HRas proto-oncogene, GTPase (Hras), Harvey rat sarcoma viral oncogene homolog L homeolog (hras.L), Harvey rat sarcoma viral oncogene homolog (hras), Harvey rat sarcoma virus oncogene (Hras), NRAS proto-oncogene, GTPase (NRAS), -Ha-ras Harvey rat sarcoma viral oncogene homolog b (hrasb), C-BAS/HAS, c-bas/has, C-H-RAS, c-H-ras, c-Ha-ras, C-HA-RAS1, c-rasHa, CTLO, H-RAS, H-Ras, H-ras, H-RASIDX, Ha-ras, HAMSV, Harvey-ras, hras, HRAS, Hras-1, HRAS1, hras1, hrasl, K-RAS, K-Ras, Kras2, N-RAS, N-Ras, ras, RASH1, rash1, zgc:110250, zgc:110734Protein level used designations for HRas proto-oncogene, GTPase
- GTP- and GDP-binding peptide B
- GTPase HRas
- H-Ras-1
- Ha-Ras1 proto-oncoprotein
- Ras family small GTP binding protein H-Ras
- c-has/bas p21 protein
- c-ras-Ki-2 activated oncogene
- p19 H-RasIDX protein
- p21ras
- transformation gene: oncogene HAMSV
- transforming protein p21
- v-Ha-ras Harvey rat sarcoma viral oncogene homolog
- xRAS1
- Transforming protein p21
- neuroblastoma ras oncogene
- c-H-ras
- v-Ha-ras Harvey rat sarcoma viral oncogene-like protein
- Harvey ras1 protein
- Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog
- ras p21
- small G-protein H-Ras
- GTPase HRas (Transforming protein p21) (H-Ras-1) (c-H-ras)
- Harvey ras 1
- H-ras 1 protein
- c-Ha-ras p21 protein
- c-Ha-ras transgene
- transforming protein P21
- GTPase NRas
- transforming protein N-Ras
- -Ha-ras Harvey rat sarcoma viral oncogene homolog b
- -Ha-ras Harvey rat sarcoma viral oncogene homolog, like
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