HNRNPU Products
(Heterogeneous Nuclear Ribonucleoprotein U (Scaffold Attachment Factor A) (HNRNPU))
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This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they form complexes with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene contains a RNA binding domain and scaffold-associated region (SAR)-specific bipartite DNA-binding domain. This protein is also thought to be involved in the packaging of hnRNA into large ribonucleoprotein complexes. During apoptosis, this protein is cleaved in a caspase-dependent way. Cleavage occurs at the SALD site, resulting in a loss of DNA-binding activity and a concomitant detachment of this protein from nuclear structural sites. But this cleavage does not affect the function of the encoded protein in RNA metabolism. At least two alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].
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Featured HNRNPU Categories
HNRNPU Antibodies
High quality antibodies with extensive validation data.
HNRNPU ELISA Kits
Reliable ELISA kits for a wide range of species.
HNRNPU Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HNRNPU Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
- (7)
Cat. No.
ABIN7101656
Quantity
20 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, IF
Validations
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Cat. No.
ABIN1680323
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Application
WB, ELISA
Validations
- (3)
Cat. No.
ABIN516594
Quantity
100 μg
Datasheet
Datasheet
Recommended HNRNPU ELISA Kits
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Reactivity
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Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
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Cat. No.
ABIN6967387
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956516
Quantity
96 tests
Datasheet
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Reactivity
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Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN1743213
Quantity
96 tests
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Recommended HNRNPU Proteins
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Reactivity
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Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306883
Quantity
10 μg
Datasheet
Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7398272
Quantity
100 μg
Datasheet
Datasheet
Reactivity
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Source
HEK-293 Cells
Validations
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Cat. No.
ABIN2722939
Quantity
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Datasheet
Datasheet
Latest Publications for our HNRNPU products
: "Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin Function." in: Cell reports, Vol. 24, Issue 4, pp. 987-1000.e7, (2018) (PubMed).: "A Prader-Willi locus lncRNA cloud modulates diurnal genes and energy expenditure." in: Human molecular genetics, Vol. 22, Issue 21, pp. 4318-28, (2013) (PubMed).
: "The nuclear scaffold protein SAF-A is required for kinetochore-microtubule attachment and contributes to the targeting of Aurora-A to mitotic spindles." in: Journal of cell science, Vol. 124, Issue Pt 3, pp. 394-404, (2011) (PubMed).
: "MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies." in: Biochemical and biophysical research communications, Vol. 414, Issue 1, pp. 259-64, (2011) (PubMed).
: "In neurons, activity-dependent association of dendritically transported mRNA transcripts with the transacting factor CBF-A is mediated by A2RE/RTS elements." in: Molecular biology of the cell, Vol. 22, Issue 11, pp. 1864-77, (2011) (PubMed).
: "MicroRNA expression profiles of human blood monocyte-derived dendritic cells and macrophages reveal miR-511 as putative positive regulator of Toll-like receptor 4." in: The Journal of biological chemistry, Vol. 286, Issue 30, pp. 26487-95, (2011) (PubMed).
: "Preferential repair of oxidized base damage in the transcribed genes of mammalian cells." in: The Journal of biological chemistry, Vol. 286, Issue 8, pp. 6006-16, (2011) (PubMed).
: "Identification of a heterogeneous nuclear ribonucleoprotein-recognition region in the HIV Rev protein." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33384-91, (2009) (PubMed).
: "Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation." in: The Journal of biological chemistry, Vol. 281, Issue 32, pp. 23180-90, (2006) (PubMed).
: "Kruppel-like factor 2 transcriptional regulation involves heterogeneous nuclear ribonucleoproteins and acetyltransferases." in: Biochemistry, Vol. 44, Issue 16, pp. 6276-85, (2005) (PubMed).
Synonyms and alternative names related to HNRNPU
heterogeneous nuclear ribonucleoprotein U (Hnrnpu), heterogeneous nuclear ribonucleoprotein U (HNRNPU), heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) S homeolog (hnrnpu.S), heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) (HNRNPU), AA408410, AI256620, AL024194, AL024437, AW557595, C86794, hnRNP U, Hnrpu, HNRPU, SAF-A, saf-a, SAFA, SN1, Sp120, U21.1Protein level used designations for HNRNPU
- SAF-A
- heterogenous nuclear ribonucleoprotein U
- nuclear matrix protein sp120
- scaffold attachment factor A
- system N1 Na+ and H+-coupled glutamine transporter
- transporter protein
- transporter protein; system N1 Na+ and H+-coupled glutamine transporter
- heterogeneous nuclear ribonucleoprotein U
- p120 nuclear protein
- pp120
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