HMGCL Products
(3-Hydroxymethyl-3-Methylglutaryl-CoA Lyase (HMGCL))
Categories
The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Featured HMGCL Categories
HMGCL Antibodies
High quality antibodies with extensive validation data.
HMGCL ELISA Kits
Reliable ELISA kits for a wide range of species.
HMGCL Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HMGCL Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p), ICC, IF
Validations
- (5)
Cat. No.
ABIN2856650
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (2)
- (3)
Cat. No.
ABIN561291
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7155995
Quantity
100 μL
Datasheet
Datasheet
Recommended HMGCL ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Validations
Cat. No.
ABIN1137676
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1137677
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Validations
Cat. No.
ABIN1137678
Quantity
96 tests
Datasheet
Datasheet
Recommended HMGCL Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306810
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN667639
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN5854983
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our HMGCL products
: "β-hydroxybutyrate protects hepatocytes against endoplasmic reticulum stress in a sirtuin 1-independent manner." in: Archives of biochemistry and biophysics, Vol. 663, pp. 220-227, (2019) (PubMed).: "The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease." in: Nature medicine, Vol. 21, Issue 3, pp. 263-9, (2015) (PubMed).
: "Characterization of a novel HMG-CoA lyase enzyme with a dual location in endoplasmic reticulum and cytosol." in: Journal of lipid research, Vol. 53, Issue 10, pp. 2046-56, (2012) (PubMed).
: "Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 21, pp. 3956-63, (2012) (PubMed).
: "Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria." in: Journal of inherited metabolic disease, Vol. 33, Issue 4, pp. 405-10, (2010) (PubMed).
Synonyms and alternative names related to HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase S homeolog (hmgcl.S), 3-hydroxymethyl-3-methylglutaryl-CoA lyase (HMGCL), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AFUA_7G01720), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (NFIA_114450), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ACLA_065820), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (AOR_1_910074), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (PMAA_004600), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TSTA_103060), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (ARB_04874), 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (TRV_06573), 3-hydroxy-3-methylglutaryl-Coenzyme A lyase (Hmgcl), 3-hydroxymethyl-3-methylglutaryl-CoA lyase (Hmgcl), 3-hydroxymethyl-3-methylglutaryl-CoA lyase (hmgcl), Afu7g01720, AO090038000541, AW476067, HL, zgc:56248Protein level used designations for HMGCL
- 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase
- 3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
- 3-hydroxy-3-methylglutarate-CoA lyase
- HL
- HMG-CoA lyase
- hydroxymethylglutaryl-CoA lyase, mitochondrial
- 3-hydroxy-3-methylglutaryl-CoA lyase
- hydroxymethylglutaricaciduria
- mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase
- 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
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