HMGA2 Products
(High Mobility Group AT-Hook 2 (HMGA2))
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This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
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Featured HMGA2 Categories
HMGA2 Antibodies
High quality antibodies with extensive validation data.
Recommended HMGA2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB
Validations
- (3)
Cat. No.
ABIN6243228
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (1)
- (2)
Cat. No.
ABIN1981306
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IF
Validations
- (2)
Cat. No.
ABIN6243227
Quantity
400 μL
Datasheet
Datasheet
Recommended HMGA2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7497089
Quantity
200 μg
Datasheet
Datasheet
Latest Publications for our HMGA2 products
: "MEG3/MIR-376B-3P/HMGA2 axis is involved in pituitary tumor invasiveness." in: Journal of neurosurgery, pp. 1-13, (2020) (PubMed).: "HMGA2 upregulation mediates Cd-induced migration and invasion in A549 cells and in lung tissues of mice." in: Chemico-biological interactions, Vol. 277, pp. 1-7, (2017) (PubMed).
: "Pancreatic cyst fluid concentration of high-mobility group A2 protein acts as a differential biomarker of dysplasia in intraductal papillary mucinous neoplasm." in: Gastrointestinal endoscopy, Vol. 83, Issue 6, pp. 1205-9, (2016) (PubMed).
: "Construction of Conveniently Screening pLKO.1-TRC Vector Tagged with TurboGFP." in: Applied biochemistry and biotechnology, (2016) (PubMed).
: "Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway." in: Molecular and cellular biology, Vol. 35, Issue 20, pp. 3547-65, (2015) (PubMed).
: "HMGA2 participates in transformation in human lung cancer." in: Molecular cancer research : MCR, Vol. 6, Issue 5, pp. 743-50, (2008) (PubMed).
: "High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma." in: Molecular cancer, Vol. 6, pp. 5, (2007) (PubMed).
: "Expression and cDNA cloning of human HMGI-C phosphoprotein." in: Biochemical and biophysical research communications, Vol. 201, Issue 1, pp. 63-70, (1994) (PubMed).
Synonyms and alternative names related to HMGA2
high mobility group AT-hook 2 (Hmga2), high mobility group AT-hook 2 (hmga2), high mobility group AT-hook 2 (HMGA2), 9430083A20Rik, BABL, HMGI-C, Hmgic, HMGIC, LIPO, pg, pygmy, STQTL9, wu:fc27f12, wu:fc28f02, wu:fc57d12, zgc:77719Protein level used designations for HMGA2
- high mobility group AT-hook protein 2
- high mobility group protein HMGI-C
- high mobility group protein I
- non-histone chromosomal architectural protein HMGI-C
- high mobility group protein I-C
- likely candidate for the autosomal dwarf locus in the chicken
- High-mobility group protein HMGI-C
- high-mobility group (nonhistone chromosomal) protein isoform I-C
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