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HLCS Products

(Biotin-Protein Ligase (HLCS))

Categories

This gene encodes an enzyme that catalyzes the binding of biotin to carboxylases and histones. The protein plays an important role in gluconeogenesis, fatty acid synthesis and branched chain amino acid catabolism. Defects in this gene are the cause of holocarboxylase synthetase deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Jun 2011].

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Featured HLCS Categories

HLCS Antibodies

High quality antibodies with extensive validation data.

HLCS ELISA Kits

Reliable ELISA kits for a wide range of species.

HLCS Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLCS Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7145611
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IP
Validations
  • (2)
Cat. No. ABIN947972
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN561280
Quantity 50 μL
Datasheet Datasheet

Recommended HLCS ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1123908
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1123909
Quantity 96 tests
Datasheet Datasheet

Recommended HLCS Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306769
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306771
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7423054
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our HLCS products

Niers, Chen, Weissleder, Tannous: "Enhanced in vivo imaging of metabolically biotinylated cell surface reporters." in: Analytical chemistry, Vol. 83, Issue 3, pp. 994-9, (2011) (PubMed).

Ingaramo, Beckett: "Distinct amino termini of two human HCS isoforms influence biotin acceptor substrate recognition." in: The Journal of biological chemistry, Vol. 284, Issue 45, pp. 30862-70, (2009) (PubMed).

Synonyms and alternative names related to HLCS

holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase) (Hlcs), holocarboxylase synthetase (HLCS), holocarboxylase synthetase (Hlcs), 410I21.SP6, D16Jhu34, HCS, RGD1565360

Protein level used designations for HLCS

  • biotin apo-protein ligase
  • biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase
  • biotin--protein ligase
  • biotin--[acetyl-CoA-carboxylase] ligase
  • biotin--[methylcrotonoyl-CoA-carboxylase] ligase
  • biotin--[methylmalonyl-CoA-carboxytransferase] ligase
  • holocarboxylase synthetase (biotin-(proprionyl-Coenzyme A-carboxylase (ATP-hydrolysing)) ligase)
  • holocarboxylase synthetase (biotin- [propriony-Coenzyme A-carboxylase (ATP-hydrolysing)] ligase)
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