HLA-DRB5 Products
(Major Histocompatibility Complex, Class II, DR beta 5 (HLA-DRB5))
Categories
HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Featured HLA-DRB5 Categories
HLA-DRB5 Antibodies
High quality antibodies with extensive validation data.
HLA-DRB5 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended HLA-DRB5 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IP
Validations
- (4)
Cat. No.
ABIN516520
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
Cat. No.
ABIN653782
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
IHC, ELISA
Validations
- (1)
Cat. No.
ABIN7246217
Quantity
200 μL
Datasheet
Datasheet
Recommended HLA-DRB5 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
- (1)
Cat. No.
ABIN6968427
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our HLA-DRB5 products
: "Molecular Characteristics of High-Dose Melphalan Associated Oral Mucositis in Patients with Multiple Myeloma: A Gene Expression Study on Human Mucosa." in: PLoS ONE, Vol. 12, Issue 1, pp. e0169286, (2017) (PubMed).Synonyms and alternative names related to HLA-DRB5
major histocompatibility complex, class II, DR beta 5 (HLA-DRB5), HLA-DRBProtein level used designations for HLA-DRB5
- DR beta-5
- DR-9
- DR2-beta-2
- DR9
- HLA class II histocompatibility antigen, DR beta 5 chain
- HLA class II histocompatibility antigen, DR-5 beta chain
- HLA class II histocompatibility antigen, DRB1-9 beta chain
- MHC HLA-DR-beta cell surface glycoprotein
- MHC HLA-DR-beta chain
- MHC class II HLA beta chain
- MHC class II antigen DRB1*9
- MHC class II antigen DRB5
- dw2
- human leucocyte antigen DRB5
- leukocyte antigen class II
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