HLA-DRB4 Products
(Major Histocompatibility Complex, Class II, DR beta 4 (HLA-DRB4))
Categories
HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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Featured HLA-DRB4 Categories
HLA-DRB4 Antibodies
High quality antibodies with extensive validation data.
HLA-DRB4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DRB4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
Cat. No.
ABIN561273
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7155609
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
Cat. No.
ABIN7246559
Quantity
200 μL
Datasheet
Datasheet
Recommended HLA-DRB4 Proteins
Synonyms and alternative names related to HLA-DRB4
major histocompatibility complex, class II, DR beta 4 (HLA-DRB4), DR-4, DR4, DRB4, HLA-DR4BProtein level used designations for HLA-DRB4
- DRB1 transplantation antigen
- HLA class II histocompatibility antigen, DR beta 4 chain
- MHC HLA DR-beta chain
- MHC class II antigen DRB4
- MHC class II antigen HLA-DR-beta
- MHC class2 antigen
- human leucocyte antigen DRB4
- leukocyte antigen
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