HLA-DRA Products
(HLA Class II DR alpha (HLA-DRA))
Categories
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008].
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Featured HLA-DRA Categories
HLA-DRA Antibodies
High quality antibodies with extensive validation data.
HLA-DRA ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-DRA Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DRA Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, FACS, ELISA, ICC
Validations
- (6)
Cat. No.
ABIN5542623
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN6141827
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (3)
Cat. No.
ABIN7437542
Quantity
100 μL
Datasheet
Datasheet
Recommended HLA-DRA ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6974906
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-DRA Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5853581
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129736
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7401032
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HLA-DRA products
: "Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 4969-4977, (2019) (PubMed).: "Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition." in: The Journal of clinical investigation, Vol. 126, Issue 8, pp. 3130-44, (2016) (PubMed).
: "Characterization and application of two RANK-specific antibodies with different biological activities." in: Immunology letters, Vol. 171, pp. 5-14, (2016) (PubMed).
: "Dermal CD14(+) Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4." in: The Journal of investigative dermatology, Vol. 135, Issue 7, pp. 1743-51, (2015) (PubMed).
: "Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune tolerance." in: Cytokine, Vol. 71, Issue 2, pp. 181-7, (2015) (PubMed).
: "Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers ..." in: Malaria journal, Vol. 12, pp. 376, (2014) (PubMed).
: "Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection." in: PLoS ONE, Vol. 9, Issue 7, pp. e102014, (2014) (PubMed).
: "Vemurafenib enhances MHC induction in BRAF(V600E) homozygous melanoma cells." in: Oncoimmunology, Vol. 2, Issue 1, pp. e22890, (2013) (PubMed).
: "Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy." in: BioMed research international, Vol. 2013, pp. 492376, (2013) (PubMed).
: "Efficient differentiation of human pluripotent stem cells into mesenchymal stem cells by modulating intracellular signaling pathways in a feeder/serum-free system." in: Stem cells and development, Vol. 21, Issue 7, pp. 1165-75, (2012) (PubMed).
Synonyms and alternative names related to HLA-DRA
major histocompatibility complex, class II, DR alpha L homeolog (hla-dra.L), major histocompatibility complex, class II, DR alpha (HLA-DRA), major histocompatibility complex, class II, DR alpha (MAMU-DRA), major histocompatibility complex, class II, DR alpha (BOLA-DRA), DR-alpha, HLA-DRA, HLA-DRA1, Mamu-DRA1, MLRWProtein level used designations for HLA-DRA
- major histocompatibility complex, class II, DR alpha
- HLA class II histocompatibility antigen, DR alpha chain
- MHC cell surface glycoprotein
- MHC class II antigen DRA
- histocompatibility antigen HLA-DR alpha
- MHC class II DRA
- MHC class II antigen
- BoLA-DR-alpha
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