HLA-DR-gamma Products
(HLA-DR-gamma (CD74))
Categories
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].
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Featured HLA-DR-gamma Categories
HLA-DR-gamma Antibodies
High quality antibodies with extensive validation data.
HLA-DR-gamma ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-DR-gamma Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DR-gamma Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS, WB, ELISA, ICC
Validations
- (2)
- (6)
Cat. No.
ABIN1724871
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7443692
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7443722
Quantity
100 μL
Datasheet
Datasheet
Recommended HLA-DR-gamma ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962624
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967449
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956587
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-DR-gamma Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274222
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
Cat. No.
ABIN7274239
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
Cat. No.
ABIN1348699
Quantity
25 μg
Datasheet
Datasheet
Latest Publications for our HLA-DR-gamma products
: "Association of variant on the promoter of cluster of differentiation 74 in graves disease and graves ophthalmopathy." in: Bioscience reports, Vol. 40, Issue 8, (2020) (PubMed).: "Examining epitope mutagenesis as a strategy to reduce and eliminate human antibody binding to class II swine leukocyte antigens." in: Immunogenetics, Vol. 71, Issue 7, pp. 479-487, (2019) (PubMed).
: "Synergy between B cell receptor/antigen uptake and MHCII peptide editing relies on HLA-DO tuning." in: Scientific reports, Vol. 9, Issue 1, pp. 13877, (2019) (PubMed).
: "Examining the Biosynthesis and Xenoantigenicity of Class II Swine Leukocyte Antigen Proteins." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 200, Issue 8, pp. 2957-2964, (2018) (PubMed).
: "Expression of macrophage migration inhibitory factor and CD74 in the inner ear and middle ear in lipopolysaccharide-induced otitis media." in: Acta oto-laryngologica, Vol. 136, Issue 10, pp. 1011-6, (2016) (PubMed).
: "Cell Surface CD74-MIF Interactions Drive Melanoma Survival in Response to Interferon-γ." in: The Journal of investigative dermatology, Vol. 135, Issue 11, pp. 2775-84, (2015) (PubMed).
: "A conserved WW domain-like motif regulates invariant chain-dependent cell-surface transport of the NKG2D ligand ULBP2." in: Molecular immunology, Vol. 66, Issue 2, pp. 418-27, (2015) (PubMed).
: "Autoantibodies against CD74 in spondyloarthritis." in: Annals of the rheumatic diseases, Vol. 73, Issue 6, pp. 1211-4, (2014) (PubMed).
: "Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells." in: Biochemical and biophysical research communications, Vol. 451, Issue 1, pp. 48-53, (2014) (PubMed).
: "CD74: a new prognostic factor for patients with malignant pleural mesothelioma." in: British journal of cancer, Vol. 110, Issue 8, pp. 2040-6, (2014) (PubMed).
Synonyms and alternative names related to HLA-DR-gamma
CD74 molecule (CD74), CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) (Cd74), CD74 molecule (Cd74), CD74 molecule, major histocompatibility complex, class II invariant chain a (cd74a), CD74 molecule, major histocompatibility complex, class II invariant chain b (cd74b), cd74, CLIP, DHLAG, HLADG, Ia-GAMMA, Iclp-1, Iclp-2, iclp1, iclp2, II, Ii, INVG34, wu:fb11f09, wu:fb12a01, wu:fb13d06, wu:fk94e07, zgc:123161Protein level used designations for HLA-DR-gamma
- CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
- HLA class II histocompatibility antigen gamma chain
- HLA-DR antigens-associated invariant chain
- HLA-DR-gamma
- Ia-associated invariant chain
- MHC HLA-DR gamma chain
- gamma chain of class II antigens
- p33
- H-2 class II histocompatibility antigen gamma chain
- HLA-DR-GAMMA
- MHC class II-associated invariant chain
- class II-associated invariant chain peptide
- dinucleotide microsatellite
- histocompatibility: class II antigens, gamma chain of
- ia antigen-associated invariant chain
- invariant polypeptide of major histocompatibility complex, class II antigen-associated
- ii
- CD74 molecule, major histocompatibility complex, class II invariant chain
- CD74 molecule, major histocompatibility complex, class II invariant chain a
- MHC II
- invariant chain-like protein 1
- invariant chain-like protein 2
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