HLA-DQB1 Products
(Major Histocompatibility Complex, Class II, DQ beta 1 (HLA-DQB1))
Categories
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
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Featured HLA-DQB1 Categories
HLA-DQB1 Antibodies
High quality antibodies with extensive validation data.
HLA-DQB1 ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-DQB1 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DQB1 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
Cat. No.
ABIN7155597
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, FACS
Validations
- (4)
Cat. No.
ABIN1327606
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
- (1)
Cat. No.
ABIN1881422
Quantity
400 μL
Datasheet
Datasheet
Recommended HLA-DQB1 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6957623
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957624
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5656621
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-DQB1 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306759
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306761
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412929
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HLA-DQB1 products
: "Follicular lymphoma-protective HLA class II variants correlate with increased HLA-DQB1 protein expression." in: Genes and immunity, Vol. 15, Issue 2, pp. 133-6, (2014) (PubMed).: "Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 80, Issue 23, pp. 7313-7, (1984) (PubMed).
: "Cloning and sequence analysis of the human major histocompatibility complex gene DC-3 beta." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 16, pp. 5199-203, (1984) (PubMed).
: "Molecular analysis of human class II transplantation antigens and their genes." in: Human immunology, Vol. 8, Issue 1, pp. 95-103, (1983) (PubMed).
: "Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 79, Issue 12, pp. 3687-91, (1982) (PubMed).
Synonyms and alternative names related to HLA-DQB1
major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), major histocompatibility complex, class II, DQ beta 1 (PATR-DQB1), major histocompatibility complex, class II, DQ beta 1 (DLA-DQB1), major histocompatibility complex, class II, DQ beta 1 (MAMU-DQB1), major histocompatibility complex, class II, DQ beta 1 (LOC100172120), CELIAC1, DKFZp469C0237, DLA-DQB, HLA-DQB, IDDM1, LOC100172120, MAMU-DQB1, mhc-DRBProtein level used designations for HLA-DQB1
- HLA class II histocompatibility antigen, DQ beta 1 chain
- MHC DQ beta
- MHC class II DQ beta chain
- MHC class II HLA-DQ beta glycoprotein
- MHC class II antigen DQB1
- MHC class II antigen HLA-DQ-beta-1
- MHC class2 antigen
- lymphocyte antigen
- MHC class II DRB antigen
- MHC class II DLA DQ beta chain
- major histocompatibility complex, class II, DQ beta 1
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