HLA-DMB Products
(Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
Categories
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
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Featured HLA-DMB Categories
HLA-DMB Antibodies
High quality antibodies with extensive validation data.
HLA-DMB Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-DMB Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IP
Validations
- (5)
Cat. No.
ABIN516478
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7189497
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP
Validations
- (3)
Cat. No.
ABIN516481
Quantity
100 μg
Datasheet
Datasheet
Recommended HLA-DMB ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Sandwich ELISA
Validations
Cat. No.
ABIN417816
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-DMB Proteins
Latest Publications for our HLA-DMB products
: "Increased HLA-DMB expression in the tumor epithelium is associated with increased CTL infiltration and improved prognosis in advanced-stage serous ovarian cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7667-73, (2008) (PubMed).: "Bioinformatics methods for prioritizing serum biomarker candidates." in: Clinical chemistry, Vol. 52, Issue 11, pp. 2162-4, (2007) (PubMed).
Synonyms and alternative names related to HLA-DMB
major histocompatibility complex, class II, DM beta (HLA-DMB), RT1 class II, locus DMb (RT1-DMb), major histocompatibility complex, class II, DM beta (PATR-DMB), D6S221E, MHC-DMB, RING7, RT1.DMb, RT1.MbProtein level used designations for HLA-DMB
- HLA class II histocompatibility antigen, DM beta chain
- MHC class II HLA-DMB
- MHC class II antigen DMB
- MHC class II antigen HLA-DM beta chain
- class II histocompatibility antigen, M beta chain
- really interesting new gene 7 protein
- MHC class II-like beta chain
- RT1 class II, DM beta
- major histocompatibility complex, class II, DM beta
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