HLA-C Products
(Major Histocompatibility Complex Class I C (HLA-C))
Categories
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].
antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.
Featured HLA-C Categories
HLA-C Antibodies
High quality antibodies with extensive validation data.
HLA-C ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-C Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-C Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7434662
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF
Validations
- (5)
Cat. No.
ABIN7155625
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IHC, IF
Validations
- (4)
Cat. No.
ABIN7155571
Quantity
100 μg
Datasheet
Datasheet
Recommended HLA-C ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6968422
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6962562
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN1571212
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-C Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123828
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2752815
Quantity
25 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN2129739
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HLA-C products
: "The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression. ..." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 14, pp. 3366-3376, (2018) (PubMed).: "Influence of HLA-C expression level on HIV control. ..." in: Science (New York, N.Y.), Vol. 340, Issue 6128, pp. 87-91, (2013) (PubMed).
: "Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression." in: Journal of virology, Vol. 85, Issue 7, pp. 3367-74, (2011) (PubMed).
: "TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide." in: Current biology : CB, Vol. 8, Issue 1, pp. 1-10, (1998) (PubMed).
Synonyms and alternative names related to HLA-C
major histocompatibility complex, class I, C (HLA-C), D6S204, HLA-JY3, HLC-C, PSORS1Protein level used designations for HLA-C
- HLA class I histocompatibility antigen, C alpha chain
- HLA class I histocompatibility antigen, Cw-1 alpha chain
- MHC class I antigen heavy chain HLA-C
- human leukocyte antigen-C alpha chain
- major histocompatibility antigen HLA-C
You are here:
