HLA B7 Products
(HLA Class I B7 Alpha (HLA B7))
Categories
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].
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Featured HLA B7 Categories
HLA B7 Antibodies
High quality antibodies with extensive validation data.
Recommended HLA B7 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Non-Human Primate
Application
FACS
Validations
- (6)
- (3)
Cat. No.
ABIN1111104
Quantity
100 tests
Datasheet
Datasheet
Reactivity
Human, Non-Human Primate
Application
FACS
Validations
- (5)
- (2)
Cat. No.
ABIN1027673
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Cynomolgus, Human
Application
FACS
Validations
- (1)
Cat. No.
ABIN305300
Quantity
0.1 mg
Datasheet
Datasheet
Recommended HLA B7 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
Cat. No.
ABIN2722838
Quantity
20 μg
Datasheet
Datasheet
Latest Publications for our HLA B7 products
: "Palmitoylation of MIR2 is required for its function." in: Journal of virology, Vol. 85, Issue 5, pp. 2288-95, (2011) (PubMed).: "Immunogenic HLA-B7-restricted peptides of hTRT." in: International immunology, Vol. 18, Issue 12, pp. 1707-18, (2006) (PubMed).
: "Rapid and sensitive identification of major histocompatibility complex class I-associated tumor peptides by Nano-LC MALDI MS/MS." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 12, pp. 1888-97, (2005) (PubMed).
: "Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)." in: Clinical and experimental immunology, Vol. 128, Issue 3, pp. 525-31, (2002) (PubMed).
: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, (2000) (PubMed).
: "Phase I study of direct intralesional gene transfer of HLA-B7 into metastatic renal carcinoma lesions." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 10, pp. 2766-72, (1999) (PubMed).
: "Immunoradiometric assay for the rapid detection of HLA-B27." in: Immunology and cell biology, Vol. 66 ( Pt 3), pp. 215-9, (1991) (PubMed).
: "Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 7, pp. 2361-4, (1989) (PubMed).
Synonyms and alternative names related to HLA B7
major histocompatibility complex, class I, B (HLA-B), AS, HLAB, SPDA1Protein level used designations for HLA B7
- HLA class I histocompatibility antigen, B alpha chain
- MHC Class I HLA heavy chain
- MHC HLA-B cell surface glycoprotein
- MHC HLA-B transmembrane glycoprotein
- MHC class I antigen GN00104
- MHC class I antigen HLA-B heavy chain
- MHC class I antigen SHCHA
- leukocyte antigen class I-B
- lymphocyte antigen
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