HLA-B27 Products
(HLA Class I Histocompatibility Antigen, B-27 alpha Chain (HLA-B27))
Categories
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].
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Featured HLA-B27 Categories
HLA-B27 Antibodies
High quality antibodies with extensive validation data.
HLA-B27 ELISA Kits
Reliable ELISA kits for a wide range of species.
Recommended HLA-B27 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
FACS
Validations
- (1)
Cat. No.
ABIN7490111
Quantity
100 tests
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF (cc), IF (p), ICC, ELISA, IHC (fro), IHC (p)
Validations
Cat. No.
ABIN1385327
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (fro), IHC (p)
Validations
Cat. No.
ABIN1399981
Quantity
100 μL
Datasheet
Datasheet
Recommended HLA-B27 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967447
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6973683
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Guinea Pig
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN777065
Quantity
96 tests
Datasheet
Datasheet
Latest Publications for our HLA-B27 products
: "Flow cytometric HLA-B27 screening: cross-reactivity patterns of commercially available anti-HLA-B27 monoclonal antibodies with other HLA-B antigens." in: Cytometry. Part B, Clinical cytometry, Vol. 54, Issue 1, pp. 28-38, (2003) (PubMed).Synonyms and alternative names related to HLA-B27
major histocompatibility complex, class I, B (HLA-B), AS, HLAB, SPDA1Protein level used designations for HLA-B27
- HLA class I histocompatibility antigen, B alpha chain
- MHC Class I HLA heavy chain
- MHC HLA-B cell surface glycoprotein
- MHC HLA-B transmembrane glycoprotein
- MHC class I antigen GN00104
- MHC class I antigen HLA-B heavy chain
- MHC class I antigen SHCHA
- leukocyte antigen class I-B
- lymphocyte antigen
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