HLA-B Products
(Major Histocompatibility Complex, Class I, B (HLA-B))
Categories
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].
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Featured HLA-B Categories
HLA-B Antibodies
High quality antibodies with extensive validation data.
HLA-B ELISA Kits
Reliable ELISA kits for a wide range of species.
HLA-B Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HLA-B Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
- (6)
Cat. No.
ABIN1944779
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7440755
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, FACS, IHC, ICC
Validations
- (7)
Cat. No.
ABIN5542339
Quantity
100 μL
Datasheet
Datasheet
Recommended HLA-B ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6957622
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN5656618
Quantity
96 tests
Datasheet
Datasheet
Recommended HLA-B Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7123829
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN2752813
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7412851
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HLA-B products
: "A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E ..." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 34895-903, (2012) (PubMed).: "Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38054-9, (2011) (PubMed).
: "Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells." in: Journal of virology, Vol. 86, Issue 1, pp. 527-41, (2011) (PubMed).
: "Further molecular diversity in the HLA-B15 group." in: Tissue antigens, Vol. 47, Issue 4, pp. 265-74, (1996) (PubMed).
: "HLA-B15: a widespread and diverse family of HLA-B alleles." in: Tissue antigens, Vol. 43, Issue 4, pp. 209-18, (1994) (PubMed).
: "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens." in: Tissue antigens, Vol. 38, Issue 4, pp. 186-90, (1992) (PubMed).
: "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 10, pp. 3411-5, (1992) (PubMed).
: "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." in: Nature, Vol. 357, Issue 6376, pp. 329-33, (1992) (PubMed).
Synonyms and alternative names related to HLA-B
major histocompatibility complex, class I, B (HLA-B), major histocompatibility complex, class I, B (BOLA-B), major histocompatibility complex, class I, B (MAMU-B18), major histocompatibility complex, class I, B (DKFZP469N1225), major histocompatibility complex nonclassical class Ib L homeolog (mhc1b.L), AS, HLAB, mhc1b, SPDA1Protein level used designations for HLA-B
- HLA class I histocompatibility antigen, B alpha chain
- MHC Class I HLA heavy chain
- MHC HLA-B cell surface glycoprotein
- MHC HLA-B transmembrane glycoprotein
- MHC class I antigen GN00104
- MHC class I antigen HLA-B heavy chain
- MHC class I antigen SHCHA
- leukocyte antigen class I-B
- lymphocyte antigen
- major histocompatibility complex, class I, B
- major histocompatibility complex nonclassical class Ib L homeolog
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