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HLA-A Products

(Major Histocompatibility Complex, Class I, A (HLA-A))

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HLA-A is a critical member of the HLA class I molecule family, essential for the immune system's functioning. Each HLA-A molecule is a heterodimer, formed by a heavy chain paired with a beta-2 microglobulin light chain. The heavy chain, embedded in cell membranes, plays a pivotal role in immune defense by presenting peptides to cytotoxic T cells. This mechanism is crucial for the body's ability to recognize and respond to pathogens.

This molecule is ubiquitously expressed across almost all cell types. The heavy chain itself is about 45 kDa in size, encoded by a gene with 8 exons. These exons encode various components of the molecule, including the leader peptide, the peptide-binding alpha1 and alpha2 domains, the alpha3 domain, the transmembrane region, and the cytoplasmic tail. Notably, genetic variations in the peptide-binding domains (encoded by exon 2 and exon 3) confer the specificity of each HLA-A molecule, making them key in determining compatibility for bone marrow and kidney transplants.

HLA-A's significance extends to its role in infectious diseases. Variations in these molecules have been implicated in the progression and outcome of diseases caused by various pathogens, such as the malaria parasite, HIV, and coronaviruses including SARS-CoV and SARS-CoV-2. The latter, responsible for the COVID-19 pandemic, has multiple Class I epitopes that interact with HLA-A molecules, highlighting the importance of individual HLA genetic differences in immune responses across populations.

antibodies-online.com stands for high-quality research products. Search, find and order tools with extensive validation data, images, references. Our scientific customer service is always at your disposal if you have any questions about the selection or application of our products.

Featured HLA-A Categories

HLA-A Antibodies

High quality antibodies with extensive validation data.

HLA-A ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-A Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended HLA-A Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (6)
Cat. No. ABIN3023100
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IF, IHC
Validations
  • (7)
Cat. No. ABIN1873024
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (4)
Cat. No. ABIN516463
Quantity 100 μL
Datasheet Datasheet

Recommended HLA-A ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6968423
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6957621
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
Cat. No. ABIN809031
Quantity 96 tests
Datasheet Datasheet

Recommended HLA-A Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1306741
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
Cat. No. ABIN6964124
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7412848
Quantity 100 μg
Datasheet Datasheet

Latest Publications for our HLA-A products

Li, Xu, Zhao, Yu, Ge, Xu: "Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 4969-4977, (2019) (PubMed).

Lawson, Ebetino, Mazur, Chantry, Paton-Hough, Evans, Lath, Tsoumpra, Lundy, Dobson, Quijano, Kwaasi, Dunford, Duan, Triffitt, Jeans, Russell: "The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 32, Issue 9, pp. 1860-1869, (2018) (PubMed).

Charpak-Amikam, Kubsch, Seidel, Oiknine-Djian, Cavaletto, Yamin, Schmiedel, Wolf, Gribaudo, Messerle, Cicin-Sain, Mandelboim: "Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20." in: Scientific reports, Vol. 7, Issue 1, pp. 8661, (2017) (PubMed).

Loubaki, Chabot, Bazin: "Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune tolerance." in: Cytokine, Vol. 71, Issue 2, pp. 181-7, (2015) (PubMed).

Klöß, Chambron, Gardlowski, Arseniev, Koch, Esser, Glienke, Seitz, Köhl: "Increased sMICA and TGFβ1 levels in HNSCC patients impair NKG2D-dependent functionality of activated NK cells." in: Oncoimmunology, Vol. 4, Issue 11, pp. e1055993, (2015) (PubMed).

Dupuy, Lambert, Zucman, Choukem, Tognarelli, Pages, Lebbé, Caillat-Zucman: "Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma." in: PLoS pathogens, Vol. 8, Issue 1, pp. e1002486, (2012) (PubMed).

Parham, Barnstable, Bodmer: "Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 123, Issue 1, pp. 342-9, (1979) (PubMed).

Synonyms and alternative names related to HLA-A

major histocompatibility complex, class I, A (HLA-A), HLAA

Protein level used designations for HLA-A

  • HLA class I histocompatibility antigen, A-1 alpha chain
  • MHC class I antigen HLA-A heavy chain
  • antigen presenting molecule
  • leukocyte antigen class I-A
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