High-Mobility Group Non-Histone Chromatin Protein Proteins
(High-Mobility Group Non-Histone Chromatin Protein (NHP6))
DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity). {ECO:0000250}.
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