HIF1AN Products
(Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
Categories
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011].
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Featured HIF1AN Categories
HIF1AN Antibodies
High quality antibodies with extensive validation data.
Recommended HIF1AN Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7441979
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IP, IF
Validations
- (6)
Cat. No.
ABIN527607
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IP, IF
Validations
- (5)
Cat. No.
ABIN7156025
Quantity
100 μg
Datasheet
Datasheet
Recommended HIF1AN ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6956649
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN454393
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Validations
Cat. No.
ABIN1137714
Quantity
96 tests
Datasheet
Datasheet
Recommended HIF1AN Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN935007
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306622
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7413922
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HIF1AN products
: "Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway." in: PLoS ONE, Vol. 14, Issue 2, pp. e0211244, (2019) (PubMed).: "Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1." in: Redox biology, Vol. 26, pp. 101265, (2019) (PubMed).
: "Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1." in: Science signaling, Vol. 9, Issue 430, pp. ra56, (2017) (PubMed).
: "miR-148a-3p Mediates Notch Signaling to Promote the Differentiation and M1 Activation of Macrophages." in: Frontiers in immunology, Vol. 8, pp. 1327, (2017) (PubMed).
: "NECAB3 Promotes Activation of Hypoxia-inducible factor-1 during Normoxia and Enhances Tumourigenicity of Cancer Cells." in: Scientific reports, Vol. 6, pp. 22784, (2016) (PubMed).
: "A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity." in: Molecular cancer research : MCR, Vol. 14, Issue 3, pp. 253-66, (2016) (PubMed).
: "Oxygen-dependent hydroxylation by FIH regulates the TRPV3 ion channel." in: Journal of cell science, Vol. 128, Issue 2, pp. 225-31, (2015) (PubMed).
: "Factor-inhibiting HIF-1 (FIH-1) is required for human vascular endothelial cell survival." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 29, Issue 7, pp. 2814-27, (2015) (PubMed).
: "Expression and DNA methylation levels of prolyl hydroxylases PHD1, PHD2, PHD3 and asparaginyl hydroxylase FIH in colorectal cancer." in: BMC cancer, Vol. 13, pp. 526, (2014) (PubMed).
: "Factor inhibiting HIF-1 (FIH-1) modulates protein interactions of apoptosis-stimulating p53 binding protein 2 (ASPP2)." in: Journal of cell science, Vol. 126, Issue Pt 12, pp. 2629-40, (2013) (PubMed).
Synonyms and alternative names related to HIF1AN
hypoxia inducible factor 1 alpha subunit inhibitor (HIF1AN), hypoxia-inducible factor 1, alpha subunit inhibitor (Hif1an), hypoxia inducible factor 1, alpha subunit inhibitor (hif1an), hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog (hif1an.S), hypoxia inducible factor 1 alpha subunit inhibitor (Hif1an), 2310046M24Rik, A830014H24Rik, cb728, FIH1, id:ibd5139Protein level used designations for HIF1AN
- FIH-1
- factor inhibiting HIF-1
- factor inhibiting HIF1
- hypoxia-inducible factor 1-alpha inhibitor
- hypoxia-inducible factor asparagine hydroxylase
- peptide-aspartate beta-dioxygenase
- hypoxia-inducible factor 1, alpha subunit inhibitor
- LOW QUALITY PROTEIN: hypoxia-inducible factor 1-alpha inhibitor
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