HDAC8 Products
(Histone Deacetylase 8 (HDAC8))
Categories
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Featured HDAC8 Categories
HDAC8 Antibodies
High quality antibodies with extensive validation data.
HDAC8 ELISA Kits
Reliable ELISA kits for a wide range of species.
HDAC8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended HDAC8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IP
Validations
- (7)
Cat. No.
ABIN7267714
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA, WB, IF
Validations
- (5)
Cat. No.
ABIN527747
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6255291
Quantity
100 μL
Datasheet
Datasheet
Recommended HDAC8 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6967441
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
Cat. No.
ABIN1380597
Quantity
2 x 96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6951139
Quantity
96 tests
Datasheet
Datasheet
Recommended HDAC8 Proteins
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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306466
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1306464
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Mouse
Source
Baculovirus infected Insect Cells
Validations
- (1)
Cat. No.
ABIN7320338
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our HDAC8 products
: "HDAC8 Regulates a Stress Response Pathway in Melanoma to Mediate Escape from BRAF Inhibitor Therapy." in: Cancer research, Vol. 79, Issue 11, pp. 2947-2961, (2019) (PubMed).: "Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6." in: EBioMedicine, Vol. 9, pp. 195-206, (2017) (PubMed).
: "HDAC8 and STAT3 repress BMF gene activity in colon cancer cells." in: Cell death & disease, Vol. 5, pp. e1476, (2014) (PubMed).
: "The tricyclic antidepressant amitriptyline inhibits D-cyclin transactivation and induces myeloma cell apoptosis by inhibiting histone deacetylases: in vitro and in silico evidence." in: Molecular pharmacology, Vol. 79, Issue 4, pp. 672-80, (2011) (PubMed).
: "Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases." in: Molecular pharmacology, Vol. 79, Issue 1, pp. 197-206, (2010) (PubMed).
: "Negative regulation of histone deacetylase 8 activity by cyclic AMP-dependent protein kinase A." in: Molecular and cellular biology, Vol. 24, Issue 2, pp. 765-73, (2003) (PubMed).
: "Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor." in: The Journal of biological chemistry, Vol. 275, Issue 20, pp. 15254-64, (2000) (PubMed).
: "Characterization of a highly complex region in Xq13 and mapping of three isodicentric breakpoints associated with preleukemia." in: Genomics, Vol. 64, Issue 3, pp. 221-9, (2000) (PubMed).
: "Cloning and characterization of human histone deacetylase 8." in: FEBS letters, Vol. 478, Issue 1-2, pp. 77-83, (2000) (PubMed).
Synonyms and alternative names related to HDAC8
histone deacetylase 8 (CC1G_05302), histone deacetylase 8 (hdac8), histone deacetylase 8 (HDAC8), histone deacetylase 8 (Hdac8), histone deacetylase 8 L homeolog (hdac8.L), histone deacetylase 8 (HDA08), 2610007D20Rik, ATHDA8, CDLS5, HD8, HDA8, HDACL1, HISTONE DEACETYLASE 8, histone deacetylase 8, MRXS6, RGD1562895, RPD3, T27G7.14, T27G7_14, WTS, wu:fd19a02, zgc:66196Protein level used designations for HDAC8
- histone deacetylase 8
- histone deacetylase-like 1
- HD8
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